Fig. 8
From: JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells
JAKi inhibit the caspase-1 (p20) release from GM-CSF-stimulated neutrophils. Neutrophils (2 × 106/ml) were stimulated with GM-CSF (20 ng/ml) for 24 h in the presence or absence of the pretreatment JAKi (tofacitinib, baricitinib, upadacitinib for 1 h). Supernatants were analyzed for caspase-1 (p20) by ELISA. Values represent the mean ± SD of three independent experiments. * p < 0.01 baricitinib-pretreated neutrophils versus those with tofacitinib or upadacitinib