| Variable | No. of trails | HR | 95%CI | P value | Heterogeneity(I2) | |
|---|---|---|---|---|---|---|
| Site of infection | ||||||
| respiratory tract | 6 | 1.15 | 1.10 | 1.20 | < 0.001 | 71% |
| others | 3 | 1.15 | 1.06 | 1.25 | < 0.001 | 50% |
| Comorbidity | ||||||
| hypertension and DM | 8 | 1.12 | 1.10 | 1.13 | < 0.001 | 81% |
| others | 3 | 1.24 | 1.14 | 1.34 | < 0.001 | 70% |
| NOS score | ||||||
| ≥ 7 | 7 | 1.13 | 1.10 | 1.17 | < 0.001 | 14% |
| < 7 | 4 | 1.31 | 1.06 | 1.62 | < 0.001 | 87% |
| Study design | ||||||
| CCS | 6 | 1.08 | 1.06 | 1.10 | < 0.001 | 75% |
| RCS | 3 | 1.14 | 1.13 | 1.16 | < 0.001 | 0% |
| PCS | 2 | 1.83 | 1.30 | 2.59 | < 0.001 | 10% |
| Region | ||||||
| Europe or North America | 2 | 1.07 | 1.05 | 1.09 | < 0.001 | 83% |
| Asia | 9 | 1.14 | 1.13 | 1.16 | < 0.001 | 53% |