Subcutaneous immunoglobulin in primary immunodeficiency – impact of training and infusion characteristics on patient-reported outcomes

Table 8 Examination of PRO model diagnostics

Type of test of models	Model discrimination (ROC curve)		Model calibration – Hosmer-Lemeshow test
Characteristics	AUC	95% CI	p-value
General health perception
	0.84	0.80, 0.89	0.78
TSQM scores
Total	0.66	0.60, 0.72	0.74
Effectiveness	0.61	0.56, 0.67	0.92
Side effects	0.69	0.64, 0.75	0.49
Convenience	0.69	0.63, 0.76	0.81
Global	0.69	0.63, 0.74	0.19
PROMIS Fatigue
	0.62	0.56, 0.68	0.29

The AUC and 95% CI summarize the discriminatory ability of the relevant PRO model. The Hosmer-Leweshow p-value summarizes the goodness of fit test under the null hypothesis of lack of fit – all values p > 0.05 suggest good calibration of the model to the data
AUC area under the curve, CI confidence interval, PRO patient-reported outcome, PROMIS Patient-Reported Outcome Management Information System, ROC receiver operating characteristic, TSQM Treatment Satisfaction Questionnaire for Medication