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Table 1 Characteristics of the study subjects

From: Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food

 

Age

Sex

Asthma

Symptomsa

sIgE to food allergens c

sIgE to pollens and moldd

sIgE to mite and animals’ dander/ epitheliume

(yr)

A

B

C

D

E

(rx6)

(rx7)

IgEneg donors

 N1

31

F

No

2

1

1

  

neg

neg

neg

 N2

20

M

No

1

2

1

  

neg

neg

neg

 N3

63

M

No

 

2

  

1

neg

neg

neg

 N4

68

F

Yes

 

1

 

2

 

neg

neg

neg

 N5

54

F

No

1

 

2

1

 

neg

neg

neg

 N6

42

F

No

2

3

   

neg

neg

neg

 N7

68

F

Yes

1

2

  

1

neg

neg

neg

 N8

66

F

 

missing

neg

neg

neg

 N9

61

M

No

1

2

  

1

neg

neg

neg

 Group median

59

IgEpos donors

 P1

36

F

Yes

  

3

  

haz

pos (birch/tim)

pos (cat/dog)

 P2

45

F

No

 

1

2

  

haz

pos (birch/tim/mugw)

pos (cat/dog/horse)

 P3

44

F

Yes

3

2

2

 

2

pea, peanut, soy, haz, wheat

pos (birch/tim/mugw)

neg

 P4

43

F

Yes

2

1

2

  

neg

pos (tim/mugw)

pos (dog)

 P5

43

F

No

2

 

2

  

pea, peanut, soy, haz, milk

pos (birch)

pos (cat)

 P6

37

F

No

2

    

chicken

neg

neg

 P7

31

F

No

 

1

1

  

haz

pos (birch/tim/mugw)

pos (cat/dog/horse)

 P8

38

F

Yes

 

3

 

2

3

peanut, haz, milk, wheat, fenu, chili, parsley

pos (birch/tim/mugw)

pos (cat/dog/horse)

 P9

62

M

No

2

    

shrimp

neg

pos (mite)

 P10

32

F

No

2

2

2

  

peanut, haz, celery

pos (birch/tim)

pos (cat, dog, horse)

 P11

24

M

Yes

   

3

 

pea, peanut, soy, haz, wheat, fenu

pos (birch/tim)

pos (cat, dog, horse)

 Group median

43

Healthy donors

 C1

57

F

No

     

neg

neg

neg

 C2

46

F

No

     

neg

neg

neg

 C3

47

M

No

     

neg

neg

neg

 C4

58

M

No

     

neg

neg

neg

 C5

40

F

No

     

neg

neg

neg

 C6

40

F

No

     

neg

neg

neg

 C7

28

M

No

     

neg

neg

neg

 C8

41

F

No

     

neg

neg

neg

 Group median

42

  1. Abbreviations: F female, M male, neg negative, pos positive, n.r. not relevant, tim timothy, mugw mugwort, haz hazelnut, fenu fenugreek
  2. aSymptoms as reported to the food allergy register at time of the adverse reaction. A: skin, B: gastrointestinal tract, C: respiratory tract, D: cardiovascular system, E: neurological system; severity of symptoms: 1 = mild, 2 = moderate, 3 = severe
  3. bSelf reported, suspected offending food (reported to the food allergy register)
  4. cPositive sIgE (> 0.35 kU/L in serum, analyzed by ImmunoCAP) to i) any of the 12 allergens in the standard panel (milk, egg, wheat, pea, soy, peanut, fenugreek, hazelnut, celery, cod, salmon and shrimp, as well as birch and timothy), ii) other allergens based on reported suspected offending food or iii) any allergen positive in the dot blot matrix. Negative sIgE denotes individuals without any detectable sIgE to the standard panel or the dot blot matrix. IgE levels in kU/L are given in supplementary Table 1
  5. drx6 comprises a mix of allergens from birch, timothy, mugwort pollens or mold (cladosporium and alternaria). If positive for sIgE to rx6, also the single allergens were analyzed by ImmunoCAP, and allergens with positive sIgE given in paranthesis. IgE levels in kU/L are given in supplementary Table 1
  6. erx7 comprises a mix of allergens from mite (D. pteronyssinus), dander from cat, horse, dog or rabbit epithelium. If positive for sIgE to rx7, also the single allergens were analyzed by ImmunoCAP, and allergens with positive sIgE given in parentheses. IgE levels in kU/L are given in supplementary Table 1
  7. *medication, alcohol and exercise are reported and may aggravate food allergic responses [17]