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Table 1 Characteristics of the study subjects

From: Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food

  Age Sex Asthma Symptomsa sIgE to food allergens c sIgE to pollens and moldd sIgE to mite and animals’ dander/ epitheliume
(yr) A B C D E (rx6) (rx7)
IgEneg donors
 N1 31 F No 2 1 1    neg neg neg
 N2 20 M No 1 2 1    neg neg neg
 N3 63 M No   2    1 neg neg neg
 N4 68 F Yes   1   2   neg neg neg
 N5 54 F No 1   2 1   neg neg neg
 N6 42 F No 2 3     neg neg neg
 N7 68 F Yes 1 2    1 neg neg neg
 N8 66 F   missing neg neg neg
 N9 61 M No 1 2    1 neg neg neg
 Group median 59
IgEpos donors
 P1 36 F Yes    3    haz pos (birch/tim) pos (cat/dog)
 P2 45 F No   1 2    haz pos (birch/tim/mugw) pos (cat/dog/horse)
 P3 44 F Yes 3 2 2   2 pea, peanut, soy, haz, wheat pos (birch/tim/mugw) neg
 P4 43 F Yes 2 1 2    neg pos (tim/mugw) pos (dog)
 P5 43 F No 2   2    pea, peanut, soy, haz, milk pos (birch) pos (cat)
 P6 37 F No 2      chicken neg neg
 P7 31 F No   1 1    haz pos (birch/tim/mugw) pos (cat/dog/horse)
 P8 38 F Yes   3   2 3 peanut, haz, milk, wheat, fenu, chili, parsley pos (birch/tim/mugw) pos (cat/dog/horse)
 P9 62 M No 2      shrimp neg pos (mite)
 P10 32 F No 2 2 2    peanut, haz, celery pos (birch/tim) pos (cat, dog, horse)
 P11 24 M Yes     3   pea, peanut, soy, haz, wheat, fenu pos (birch/tim) pos (cat, dog, horse)
 Group median 43
Healthy donors
 C1 57 F No       neg neg neg
 C2 46 F No       neg neg neg
 C3 47 M No       neg neg neg
 C4 58 M No       neg neg neg
 C5 40 F No       neg neg neg
 C6 40 F No       neg neg neg
 C7 28 M No       neg neg neg
 C8 41 F No       neg neg neg
 Group median 42
  1. Abbreviations: F female, M male, neg negative, pos positive, n.r. not relevant, tim timothy, mugw mugwort, haz hazelnut, fenu fenugreek
  2. aSymptoms as reported to the food allergy register at time of the adverse reaction. A: skin, B: gastrointestinal tract, C: respiratory tract, D: cardiovascular system, E: neurological system; severity of symptoms: 1 = mild, 2 = moderate, 3 = severe
  3. bSelf reported, suspected offending food (reported to the food allergy register)
  4. cPositive sIgE (> 0.35 kU/L in serum, analyzed by ImmunoCAP) to i) any of the 12 allergens in the standard panel (milk, egg, wheat, pea, soy, peanut, fenugreek, hazelnut, celery, cod, salmon and shrimp, as well as birch and timothy), ii) other allergens based on reported suspected offending food or iii) any allergen positive in the dot blot matrix. Negative sIgE denotes individuals without any detectable sIgE to the standard panel or the dot blot matrix. IgE levels in kU/L are given in supplementary Table 1
  5. drx6 comprises a mix of allergens from birch, timothy, mugwort pollens or mold (cladosporium and alternaria). If positive for sIgE to rx6, also the single allergens were analyzed by ImmunoCAP, and allergens with positive sIgE given in paranthesis. IgE levels in kU/L are given in supplementary Table 1
  6. erx7 comprises a mix of allergens from mite (D. pteronyssinus), dander from cat, horse, dog or rabbit epithelium. If positive for sIgE to rx7, also the single allergens were analyzed by ImmunoCAP, and allergens with positive sIgE given in parentheses. IgE levels in kU/L are given in supplementary Table 1
  7. *medication, alcohol and exercise are reported and may aggravate food allergic responses [17]