Fig. 1

Generation of Collaborative Cross mice. a. This unique panel of genetically diverse mice was generated by interbreeding 8 unique and genetically diverse founder strains of mice that included 3 inbred laboratory strains (C57BL/6, A/J, 129S1/SvImJ), 2 inbred mouse models of disease (NOD/ShiLtJ-type 1 diabetes and New Zealand-obese/type 2 diabetes mice) and 3 wild-derived strains (CAST/EiJ, PWK/PhJ, and Watkins star line B (WSB)/EiJ mice). Each strain was assigned both a letter (A–H) and a specific color. b A combinational funnel breeding scheme was used to produce offspring with equal distribution of founder alleles. This figure illustrates the specific breeding funnel for the generation of the CC strain CC001. c Color illustration of founder genome contributions to CC001 strain. Reproduced from [54] with permission