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Fig. 3 | BMC Immunology

Fig. 3

From: Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients

Fig. 3

NK cells function was impaired in HSP and HSPN patients (a) NK cells from indicated groups were co-incubated with K562 target cells for 6 h at 10: 1 effecter/target ratio. The percentage of K562 cells lysed were analyzed. b, c The MFI of perforin and granzyme B were determined by flow cytometry. d The percentage of IFN-γ + NK cells were shown. Results were expressed as mean ± SEM. n = 10, *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA and Tukey’s multiple comparisonsStudent’s t test). e, f Isolated NK cells were treated with IL-15 (10 ng/ml), IL-2 (20 ng/ml) and IL-12 (30 ng/ml) for 18 h. The supernatants were collected and assayed for IFN-γ and perforin by ELISA. Results were expressed as mean ± SEM. n = 15, *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA and Tukey’s multiple comparisons)

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