Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Kousha, Ahmad; Mahdavi Gorabi, Armita; Forouzesh, Mehdi; Hosseini, Mojgan; Alexander, Markov; Imani, Danyal; Razi, Bahman; Mousavi, Mohammad Javad; Aslani, Saeed; Mikaeili, Haleh

doi:10.1186/s12865-020-00384-7

Table 1 Characteristics of studies included in meta-analysis of overall asthma

From: Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Study author	Year	Country	Ethnicity 1 (Continent)	Ethnicity 2	Ethnicity 3	Age group	Total cases/control	Genotyping method	Quality Score
Walley et al. [29]	1996	UK	Europe	non East-Asian	Caucasian	Pediatric	124 / 59	PCR-RFLP	6
Hijazi et al. [30]	2000	Kuwait	Asia	non East-Asian	Arab	Mixed	84 / 100	PCR-RFLP	6
Sandford et al. [31]	2000	New Zealand	Europe	non East-Asian	Caucasian	Adult	233 / 143	PCR-RFLP	7
Takabayashi et al. [32]	2000	Japan	Asia	East-Asian	Caucasian	Pediatric	100 / 100	PCR-RFLP	6
Hakonarson et al. [33]	2001	Iceland	Europe	non East-Asian	Caucasian	Mixed	94 / 94	PCR	6
Cui et al. [34]	2003	China	Asia	East-Asian	Caucasian	Mixed	241 / 175	PCR-RFLP	7
Basehore et al. (i) [16]	2004	USA	America	non East-Asian	African American	Adult	233 / 245	PCR	7
Basehore et al. (ii) [16]	2004	USA	America	non East-Asian	African American	Adult	168 / 269	PCR	7
Basehore et al. (iii) [16]	2004	USA	America	non East-Asian	African American	Adult	116 / 130	PCR	6
Lee et al. [35]	2004	Korea	Asia	East-Asian	Caucasian	Pediatric	254 / 100	PCR-RFLP	6
Park et al. [36]	2004	Korea	Asia	East-Asian	Caucasian	Mixed	532 / 170	SNaPshot	8
Wang et al. [37]	2004	China	Asia	East-Asian	Caucasian	Adult	93 / 62	PCR-RFLP	6
Adjers et al. [38]	2004	Finland	Europe	non East-Asian	Caucasian	Adult	243 / 401	PCR-RFLP	7
Donfack et al. (i) [26]	2005	USA	America	non East-Asian	African American	Mixed	126/ 205	LAS	6
Donfack et al. (ii) [26]	2005	USA	America	non East-Asian	African American	Mixed	205 / 183	LAS	7
Zhang et al. (i) [27]	2005	China	Asia	East-Asian	Caucasian	Adult	152 / 157	PCR-RFLP	6
Zhang et al. (ii) [27]	2005	Malaysia	Asia	East-Asian	Caucasian	Adult	76 / 100	PCR-RFLP	6
Zhang et al. (iii) [27]	2005	India	Asia	non East-Asian	Caucasian	Adult	87 / 103	PCR-RFLP	6
Gervaziev et al. [39]	2006	Russia	Europe	non East-Asian	Caucasian	Adult	109 / 68	PCR-RFLP	6
Schubert et al. [40]	2006	Germany	Europe	non East-Asian	Caucasian	Pediatric	231 / 270	PCR-RFLP	7
Kabesch et al. [41]	2006	Germany	Europe	non East-Asian	Caucasian	Pediatric	73 / 773	PCR-RFLP	6
Battle et al. [42]	2007	USA	America	non East-Asian	African American	Mixed	255 / 175	PCR-RFLP	6
Hosseini-Farahabadi et al. [43]	2007	Iran	Asia	non East-Asian	Caucasian	Adult	30 / 50	PCR-RFLP	5
Kamali-Sarvestani et al. [44]	2007	Iran	Asia	non East-Asian	Caucasian	Adult	149 / 112	PCR-RFLP	6
Chiang et al. [45]	2007	China	Asia	East-Asian	Caucasian	Adult	167 / 111	PCR-RFLP	6
Mak et al. [46]	2007	China	Asia	East-Asian	Caucasian	Adult	289 / 292	PCR-RFLP	7
Attab et al. [47]	2008	Jordan	Asia	non East-Asian	Arab	Pediatric	40 / 40	PCR-RFLP	5
De Faria et al. [48]	2008	Brazil	America	non East-Asian	Caucasian	Pediatric	88 / 202	PCR-RFLP	6
Jiang et al. [49]	2009	China	Asia	East-Asian	Caucasian	Adult	13 / 13	PCR-RFLP	5
Amirzargar et al. [50]	2009	Iran	Asia	non East-Asian	Caucasian	Mixed	59 / 139	PCR-RFLP	6
Daley et al. [51]	2009	Australia	Oceania	non East-Asian	Caucasian	Mixed	644 / 751	Illumina Bead array system	8
Haller et al. [52]	2009	USA	America	non East-Asian	African American	Adult	72 / 70	PCR-RFLP	6
Rad et al. [53]	2010	Iran	Asia	non East-Asian	Caucasian	Adult	64 / 65	PCR-RFLP	6
Wu et al. [54]	2010	China	Asia	East-Asian	Caucasian	Pediatric	252 / 227	PCR-RFLP	7
Beghe et al. [55]	2010	UK and Italy	Europe	non East-Asian	Caucasian	Mixed	299 / 176	PCR-RFLP	7
Bijanzadeh et al. [56]	2010	India	Asia	non East-Asian	Caucasian	Mixed	100 / 50	PCR-RFLP	6
Fance et al. [57]	2010	China	Asia	East-Asian	Caucasian	Adult	62 / 30	PCR-RFLP	6
Baye et al. (i) [28]	2011	USA	America	non East-Asian	African American	Pediatric	413 / 298	Illumina GoldenGate Assay system	7
Baye et al. (ii) [28]	2011	USA	America	non East-Asian	African American	Pediatric	315 / 51	Illumina GoldenGate Assay system	6
Daneshmandi et al. [58]	2011	Iran	Asia	non East-Asian	Caucasian	Adult	81 / 124	PCR-RFLP	7
Huang et al. [59]	2011	China	Asia	East-Asian	Caucasian	Pediatric	100 / 122	PCR-RFLP	6
Hwang et al. [60]	2012	China	Asia	East-Asian	Caucasian	Pediatric	188 / 376	PCR-RFLP	7
Chiang et al. [61]	2012	China	Asia	East-Asian	Caucasian	Adult	452 / 106	PCR-RFLP	6
Micheal et al. [62]	2013	Pakistan	Asia	non East-Asian	Caucasian	Mixed	108 / 120	PCR-RFLP	6
Ricciardolo et al. [63]	2013	Italy	Europe	non East-Asian	Caucasian	Mixed	57 / 124	PCR-SSP	6
Smolnikova et al. [64]	2013	Russia	Europe	non East-Asian	Caucasian	Mixed	64 / 50	PCR-RFLP	6
Li et al. [65]	2014	China	Asia	East-Asian	Caucasian	Pediatric	491 / 503	PCR-LDR	7
Wang et al. [66]	2015	China	Asia	East-Asian	Caucasian	Mixed	392 / 849	Mass array	7
Dahmani et al. [67]	2016	Algeria	Africa	non East-Asian	Arab	Adult	44 / 19	PCR-RFLP	6
Li et al. [68]	2016	China	Asia	East-Asian	Caucasian	Pediatric	317 /351	PCR and Sequencing	7
Narozna et al. [69]	2016	Poland	Europe	non East-Asian	Caucasian	Mixed	177 / 189	Taq Man	7
Zhang et al. [68]	2016	China	Asia	East-Asian	Caucasian	Pediatric	38 / 35	PCR and Sequencing	6
Hussein et al. [70]	2017	Iraq	Asia	non East-Asian	Arab	Mixed	48 / 25	ARMS-PCR	6
Abood et al. [71]	2018	Iraq	Asia	non East-Asian	Arab	Mixed	100 / 100	AS-PCR	6
Zhang et al. [72]	2019	China	Asia	East-Asian	Caucasian	Pediatric	37 / 29	PCR and Sequencing	5

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