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Table 2 PSG effect on the cytokine/chemokine profile of the Th17-polarized CD4+ cell culture

From: The effects of human pregnancy-specific β1-glycoprotein preparation on Th17 polarization of CD4+ cells and their cytokine profile

Cytokine (pg/mL) Control PSG concentration
1 μg/mL 10 μg/mL 100 μg/mL
IL-2 335,63 (245,64-442,40) 291,51 (205,12-614,36) 283,09 (196,76-597,03) 245,33 (220,51-360,54)
IL-4 11,7 (10,66-13,06) 11,26 (8,98-12,65) 10,10 (8,79-11,36) 10,46 *(9,21-11,21)
IL-5 275,23 (255,28-292,34) 281,69 (231,28-294,73) 240,85 (231,14-281,29) 226,75 *(215,79-245,03)
IL-7 2,44 (2,08-2,63) 1,73 (1,57-2,73) 2,51 (1,61-2,81) 1,73 (1,61-1,79)
IL-8 2568 (1774–3204) 1748,39 (1084,57–2207,15) 1632,86 (1512,27-3047,92) 1807,68 *(1109,83-2386,00)
IL-10 1125,84 (968,65-1605,55) 728,61 (387,41-1330,60) 634,33 *(576,84-843,67) 321,45 *(255,58-745,42)
IL-12 7,18 (6,19-8,15) 6,71 (6,28-7,95) 6,81 (6,17-8,52) 5,80 *(5,70-7,11)
IL-13 360,56 (301,15-506,65) 271,43 (238,28–774,10) 252,04 (185,75-305,85) 165,30 *(109,11-295,97)
IL-17 7836 (6093–8037) 7873,86 (1328,34-8082,78) 3239,92 (1611,37-7955,67) 2966,21 *(1280,53-5110,84)
G-CSF 35,45 (25,44-42,35) 24,52 (19,87-28,87) 22,24 (17,49-31,48) 19,39 *(16,79-23,40)
GM-CSF 651,87 (524,99-786,04) 432,00 (260,92-653,92) 321,18 (186,05-508,75) 237,85 *(67,11-275,20)
IFN-ɣ 987,56 (746,74-1142,26) 764,75 (605,65-1125,11) 609,74 *(417,27-693,11) 381,27 *(236,37-726,22)
MCP-1 39,62 (37,53-43,76) 37,86 (32,58-40,98) 36,87 (26,57-43,23) 35,46 (30,97-45,22)
MIP-1β 1844,29 (1702,16-1878,91) 1851,78 (980,31-1891,95) 1177,67 *(794,94-1827,56) 884,21 *(694,04-1572,02)
TNF-α 7357,46 (6516,69-14,856,20) 4349,65 (2888,17-9145,45) 3908,57 *(2726,18-6163,68) 3494,69 *(2965,56-4781,27)
  1. n = 11; Medians with interquartile range (Me(Q1-Q3)) are presented. Control – the CD4+ cell culture without PSG, but with TCR-activator, IL-1β, and IL-6. * - Significant differences (P < 0.05) compared with the control by the Friedman test with Dunn’s multiple comparisons test