Table 2 PSG effect on the cytokine/chemokine profile of the Th17-polarized CD4+ cell culture
Cytokine (pg/mL) | Control | PSG concentration | ||
|---|---|---|---|---|
1 μg/mL | 10 μg/mL | 100 μg/mL | ||
IL-2 | 335,63 (245,64-442,40) | 291,51 (205,12-614,36) | 283,09 (196,76-597,03) | 245,33 (220,51-360,54) |
IL-4 | 11,7 (10,66-13,06) | 11,26 (8,98-12,65) | 10,10 (8,79-11,36) | 10,46 *(9,21-11,21) |
IL-5 | 275,23 (255,28-292,34) | 281,69 (231,28-294,73) | 240,85 (231,14-281,29) | 226,75 *(215,79-245,03) |
IL-7 | 2,44 (2,08-2,63) | 1,73 (1,57-2,73) | 2,51 (1,61-2,81) | 1,73 (1,61-1,79) |
IL-8 | 2568 (1774–3204) | 1748,39 (1084,57–2207,15) | 1632,86 (1512,27-3047,92) | 1807,68 *(1109,83-2386,00) |
IL-10 | 1125,84 (968,65-1605,55) | 728,61 (387,41-1330,60) | 634,33 *(576,84-843,67) | 321,45 *(255,58-745,42) |
IL-12 | 7,18 (6,19-8,15) | 6,71 (6,28-7,95) | 6,81 (6,17-8,52) | 5,80 *(5,70-7,11) |
IL-13 | 360,56 (301,15-506,65) | 271,43 (238,28–774,10) | 252,04 (185,75-305,85) | 165,30 *(109,11-295,97) |
IL-17 | 7836 (6093–8037) | 7873,86 (1328,34-8082,78) | 3239,92 (1611,37-7955,67) | 2966,21 *(1280,53-5110,84) |
G-CSF | 35,45 (25,44-42,35) | 24,52 (19,87-28,87) | 22,24 (17,49-31,48) | 19,39 *(16,79-23,40) |
GM-CSF | 651,87 (524,99-786,04) | 432,00 (260,92-653,92) | 321,18 (186,05-508,75) | 237,85 *(67,11-275,20) |
IFN-ɣ | 987,56 (746,74-1142,26) | 764,75 (605,65-1125,11) | 609,74 *(417,27-693,11) | 381,27 *(236,37-726,22) |
MCP-1 | 39,62 (37,53-43,76) | 37,86 (32,58-40,98) | 36,87 (26,57-43,23) | 35,46 (30,97-45,22) |
MIP-1β | 1844,29 (1702,16-1878,91) | 1851,78 (980,31-1891,95) | 1177,67 *(794,94-1827,56) | 884,21 *(694,04-1572,02) |
TNF-α | 7357,46 (6516,69-14,856,20) | 4349,65 (2888,17-9145,45) | 3908,57 *(2726,18-6163,68) | 3494,69 *(2965,56-4781,27) |