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Fig. 7 | BMC Immunology

Fig. 7

From: Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients

Fig. 7

Correlation of candidate miRNAs with EV numbers and oxidative stress associated metabolites. a. Metabolites associated with oxidative stress and immune activation are increased in HIV-positive versus HIV-negative subjects. Medians are represented by horizontal bars, boxes span the IQR, and whiskers extend to extreme data points within 1.5 times IQR. Outliers are plotted outside 1.5 times the IQR. P-values were calculated by Mann-Whitney test (n = 8 HIV-negative, n = 8 HIV-positive subjects). Scatter plots show correlation of miR-21-5p, miR-27b-3p, miR-146a-5p, and miR-423-5p with EV numbers (b) and oxidative stress associated metabolites cystine, cysteine, cysteine-s-sulfate, and cys-gly, oxidized (c) in HIV-positive (n = 8) and HIV-negative (n = 8) subjects. Correlation coefficients and p-values are shown above each plot. K:T ratio, kynurenine:tryptophan ratio; RQ, relative quantity

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BMC Immunology

ISSN: 1471-2172

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