Table 1 Association of sex and allele frequency of the rs2232365 polymorphism in patients with chronic diseases, stratified according to the clinical-pathological profile
| Sex |
Alleles (rs2232365) Female (%) |
Alleles (rs2232365) Male (%) | Multiple logistic regression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Female (323) | Male (373) | Statistica | T | C | Statistica | T | C | Statistica | ||
| Group | 349 (54.03) | 297 (45.98) | – | 188 (50.40) | 185 (49.60) | – | ||||
| CVLD | 39 (12.07) | 62 (16.62) | 0.07 | 39 (50.00) | 39 (50.00) | 0.47 | 31 (50.00) | 31 (50.00) | 0.55 | NS |
| HTLV-1 | 44 (13.62) | 23 (06.16) | 0.03 1.91 (1.10–3.33) | 52 (59.09) | 36 (40.91) | 0.62 | 7 (33.33) | 16 (66.67) | 0.05 0.36 (0.14–0.92) |
Sex*: 2.11 (1.18–3.75) T*: 0.43 (0.20–0.95) |
| CAD | 91 (28.17) | 139 (37.27) | 0.02 1.53 (1.08–2.16) | 93 (51.10) | 89 (48.90) | 0.41 | 68 (48.92) | 71 (51.08) | 0.35 |
Sex*: 1.44 (0.95–2.19) |
| CG | 149 (46.13) | 149 (39.95) | 165 (55.40) | 133 (44.63) | 82 (54.31) | 67 (45.70) | ||||
| Inflammation (CVLD) | ||||||||||
| A0-A1 | 24 (61.54) | 43 (69.35) | 0.52 | 24 (50.00) | 24 (50.00) | 1.0 | 20 (57.90) | 23 (53.49) | 0.58 | |
| A2-A3 | 15 (38.46) | 19 (30.65) | 15 (50.00) | 15 (50.00) | 11 (46.51) | 8 (42.11) | ||||
| Fibrosis (CVLD) | ||||||||||
| F0-F1 | 20 (51.28) | 29 (46.77) | 0.82 | 20 (50.00) | 20 (50.00) | 1.0 | 10 (34.48) | 19 (65.52) | 0.05 4.18 (1.13–15.4) |
T*: 1.11 (0.43–2.90) |
| F2 | 8 (20.51) | 17 (27.42) | 8 (50.00) | 8 (50.00) | 10 (58.82) | 7 (41.18) | ||||
| F3-F4 | 11 (28.21) | 16 (25.81) | 11 (50.00) | 11 (50.00) | 11 (68.75) | 5 (31.25) | ||||
| HTLV-1 | ||||||||||
| Asymptomatic | 27 (61.36) | 13 (61.90) | 1.0 | 32 (59.26) | 22 (40.74) | 0.86 | 4 (30.77) | 9 (69.23) | 0.87 | |
| HAM/TSP | 17 (38.64) | 8 (38.10) | 20 (58.82) | 14 (41.18) | 3 (37.50) | 5 (62.50) | ||||
| Risky infections (CAD) | ||||||||||
| Chlamydia+ | 78 (85.71) | 121 (87.05) | 0.84 | 80 (86.02) | 74 (85.06) | 1.0 | 60 (88.24) | 61 (85.92) | 0.80 | |
| Chlamydia- | 13 (14.29) | 18 (12.95) | 13 (13.98) | 13 (14.94) | 8 (11.76) | 10 (14.08) | ||||
| Species of Chlamydia | ||||||||||
| C. pneumoniae | 55 (70.51) | 82 (67.77) | 0.74 | 58 (70.73) | 56 (66.67) | 0.99 | 43 (71.67) | 39 (63.93) | 0.50 | |
| C. trachomatis | 3 (03.85) | 3 (02.48) | 2 (02.44) | 2 (02.38) | 2 (03.33) | 1 (01.64) | ||||
| Coinfection | 20 (25.64) | 36 (29.75) | 22 (26.83) | 20 (23.81) | 15 (25.00) | 21 (34.43) | ||||