Fig. 3

D-mannose reduced autoantibody production, lymphoid expansion as well as B cell differentiation in the cGVHD model. a. Experimental design. b. Serum anti-dsDNA IgG. c. Representative FACS plots of B cells showing the GC B cell and plasma cell gates. Spleen and mLN cell numbers. Frequency (e) and number (f) of B cells in spleen and mLN. g. MHC-II MFI on splenic B cells expressed as fold change relative to the Ctrl group. Frequency and number of GC B cells (h and i) and plasma cells (j and k) in spleen and mLN. Mean ± S.E.M of n = 9–12 per group from 2 to 3 cohorts compared with t tests. *: p < 0.05