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Fig. 3 | BMC Immunology

Fig. 3

From: Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Fig. 3

Cytokine/chemokine analysis of sera and spleen preparations from BALB/c mice after aerosol exposure to clinical strains of B. pseudomallei. The cytokine/chemokine levels in a total of 63 surviving mice were evaluated at least once in duplicate in addition to 10 naïve mice. Levels of up to twenty of cytokines/chemokines were evaluated although the results of only 17/20 are shown for the different groups (Additional file 2: Table S1). A. Only 9/17 cytokines/chemokines were significantly elevated in sera from mice with chronically infected spleens (Gp 4) compared to that in sera from naïve mice (Gp 1), and those that were elevated more than 2-fold over naïve mice are shown. B. In spleen extracts the amounts of 14/17 cytokines/chemokines were significantly elevated in spleens from chronically infected mice (Gp 4), and we show 11/14 that were more than 2-fold over the levels in spleen extracts from naïve mice. Note the difference in the scale in the fold-increase between the sera and spleen extracts. The dotted line represents 5-fold increase in amounts in both figures for perspective. The significant differences are reported between the amount in naïve mice versus the amount in chronically infected mice (Gp 4): ¶, P < 0.01; §, P < 0.001; ‡, P < 0.0001

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BMC Immunology

ISSN: 1471-2172

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