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Fig. 7 | BMC Immunology

Fig. 7

From: Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Fig. 7

A schematic representation of the B. pseudomallei chronic pyogranulomatous lesion. The diagram shows a pyogranulomatous lesion with a central area of necrosis that contains the pathogen which is surrounded by more intact cells. Cells in the latter region consist of a mixture of macrophages, NK cells, neutrophils, and other lymphocytes. The inflammatory cells (macrophages, NK cells, neutrophils) are the main source of TNF-α, IFN-γ, IL-1α, and IL-1β. The expression of the latter two proinflammatory cytokines by inflammatory cells may be in response to signals from cells undergoing necrosis [64], or caspase-1 dependent/independent pyroptosis [65,66,67,68,69]. In many instances we saw a layer of epithelioid macrophages surrounding the pyogranulomatous lesion with some cells that expressed proinflammatory cytokines TNF-α, IFN-γ, IL-1α, and IL-1β

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BMC Immunology

ISSN: 1471-2172

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