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Table 3 Chronically infected mice show elevated antibody levels after infection with clinical strains of B. pseudomallei

From: Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Groupb

 

Antibody Titera

 

Ratio

 

IgG

IgG1

IgG2a

IgG2a/IgG1

Gp. 1. Naïve (10)

50 (1.00)c

50 (1.00)c

50 (1.00)c

1.00

Gp. 2. Normal Appearing (32)e

58 (1.10)

53 (1.05)

50 (1.00)c

0.94

Gp. 3. Swollen (8)e

28,537 (2.45) P = 0.0002d

10,089 (2.12) P = 0.0002d

22,307 (3.17) P = 0.0019d

2.21

Gp. 4. Chronically Infected(23)e

201,364 (1.24) P < 0.0001d

68,046 (1.33) P < 0.0001d

82,328 (1.34) P < 0.0001d

1.21

  1. a Antibody titers were done in triplicate for each mouse at least once, and titers are reported as geometric mean with geometric SEM
  2. b There was a total of 63 sera from exposed BALB/c mice. The number in parentheses represents the number of mice in each group
  3. c The number 50 was used for calculation of statistics although the antibody titers were less than 50
  4. d The significant levels are derived from comparing antibody levels for specific groups with those of naïve (Gp 1) mice
  5. e The exposure strain and number of mice (in parenthesis) in each group as follows: Gp. 2, MSHR5855 (7), HBPUB10134a (8), 406e (3), MSHR668 (5), MSHR5848 (6), K96243 (3); Gp. 3, 406e (1), 1026b (1), MSHR668 (1), MSHR5848 (1), MSHR305 (1), K96243 (1), 1106a (2); Gp. 4, MSHR5855 (1), 406e (2), 1026b (3), MSHR668 (1), MSHR5848 (1), MSHR5858 (4), MSHR305 (3), K96243 (2), 1106a (6)
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BMC Immunology

ISSN: 1471-2172

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