Fig. 1

Mice infected with C.sinensis metacercariae. a C.sinensis metacercariae were collected from fish and examination by microscope. b C.sinensis + CIA group. Histological of liver tissues from C. sinensis-infected mice stained with hematoxylin and eosin (H&E). Histological structure of liver was destroyed. Massive inflammatory cells infiltrated around the portal area accompanied by collagen hyperplasia and cholangiocyte proliferation. c, d CIA group and Control group. Histological of liver tissues from the CIA and control group mice stained with hematoxylin and eosin (H&E). In both the CIA and control group, the histological structure of liver in mice was normal, without inflammatory cell infiltration and collagen hyperplasia