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Fig. 1 | BMC Immunology

Fig. 1

From: The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer

Fig. 1

Guadecitabine treatment results in smaller tumors and a reduction in myeloid cells. 4 T1 tumor-bearing mice were untreated or treated with guadecitabine on days 10–13. a Final volume of excised tumors on day 16. b Representative images of frozen tumor sections stained with TUNEL to detect apoptotic cells. Total cellularity (top) and number of MDSCs (bottom) from c spleen, d bone marrow, and e blood. f Surface expression of APC costimulatory markers on splenic MDSCs. Significance determined using student’s unpaired T test (a), ANOVA with Tukey’s (c-e) or Sidak’s (f) multiple comparison tests. Error bars represent SD. ns = not significant; **:p value< 0.0021; ***:p value< 0.0002; ****:p value< 0.00001

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BMC Immunology

ISSN: 1471-2172

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