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Fig. 1 | BMC Immunology

Fig. 1

From: Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program

Fig. 1

Classes of immunoglobulins specific to VEGF and blocking activity in vaccinated patients during the induction phase. a IgG, IgM and IgA specific antibody titers expressed as reciprocal value. Pre-vaccination antibody titer (week 0) was subtracted from the post-vaccination antibody titer (VEGF-specific antibody titer). Post-vaccination serum samples were taken 1 week after the eighth or ninth immunization. Horizontal bars represent the median of specific antibody titer, which are shown for each class of immunoglobulin with its corresponding value. Empty or filled symbols represent patients with positive or negative serum sample, respectively. To declare a given sample taken during vaccination to be positive for antibody, eqs. 1 and 2 were used (b) Blocking activity on the VEGF/VEGFR2 or VEGF/VEGFR1 bindings. Patients that has shown at least one serum sample with neutralizing anti-VEGF antibodies were considered with a positive blocking activity. To declare a given sample taken during vaccination to be positive, eq. 4 was used

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