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Table 2 Patients with different clinical conditions vaccinated with CIGB-247 and treated with different cancer therapies

From: Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program

Patient codeDiagnosisMetastasesRelevant informationImmunogenicity/Safety profile
UC-CH47Breast carcinomaLungCardiopathy patient that received CIGB-247 simultaneous with QT (Capecitabine and Letrozol).Patient positive for anti-VEGF antibody response. Physician did not report any negative incidence on heart disease.
UC-CH77Breast carcinomaBonesPatient that received CIGB-247 simultaneous with QT (Capecitabine, Zoledronic acid) and TrastuzumabPatient positive for anti-VEGF antibody response.
UC-CH49Ovary ADCPeritoneumPatient that received CIGB-247 simultaneous with QT (Docetaxel, Carboplatin)Patient positive for anti-VEGF antibody response.
UC-HA03Ovary ADCContralateral ovaryPatient that received CIGB-247 simultaneous with QT (Paclitaxel, Carboplatin) and G-CSFPatient positive for anti-VEGF antibody response.
UC-HA07Ovary ADCContralateral ovaryPatient that received CIGB-247 simultaneous with QT (Taxol, Cisplatin)Patient positive for anti-VEGF antibody response.
UC-CQ108Bladder ADCLungPatient that received CIGB-247 simultaneous with QT (Gemcitabine, Carboplatin)Patient positive for anti-VEGF antibody response.
UC-CH10Hodgkin lymphomaLNPatient that received CIGB-247 simultaneous with QT (Procarbazine, Vincristine) and prednisonePatient positive for anti-VEGF antibody response.
UC-CH11SCLCNeck, contralateral pulmonary metastasesPatient that received CIGB-247 simultaneous with QT (Cisplatin, Etoposide (VP-16), taxol, vincristine) and G-CSF.Patient positive for anti-VEGF antibody response.
UC-CQ105Rectum ADCVaccination with CIGB-247 was applied simultaneous with QT (Capecitabine)Patient positive for anti-VEGF antibody response.
UC-HA01Peritoneum carcinomaPatient that received CIGB-247 simultaneous with QT (Docetaxel, Paclitaxel) and submitted to a major abdominal surgery (phlegmon).Patient positive for anti-VEGF antibody response. Physician did not report any negative incidence on wound healing.
UC-CH22Breast carcinomaContralateral breast and LNAfter fifth vaccination with CIGB-247, patient was submitted to urgency surgery (right tubo-ovarian abscess) and immunization was not interrupted.Patient positive for anti-VEGF antibody response a. Physician did not report any negative incidence on wound healing.
UC-HA14Ovary ADCInsulin-dependent diabetic patient with oral administration of metforminPatient positive for anti-VEGF antibody response. Physician did not report any negative incidence on diabetes condition.
UC-CH48Ovary carcinomaLiver, brain, peritoneumPatient diagnosed with diabetes mellitusPatient positive for anti-VEGF antibody response. Physician did not report any negative incidence on diabetes condition.
UC-CH08Malignant pleural mesotheliomaCardiopathy patient with diabetes mellitusPatient positive for anti-VEGF antibody response. Physician did not report any negative incidence on chronic diseases.
UC-CH38OsteosarcomaLungPatient with controlled-chronic bronchial asthmaPatient positive for anti-VEGF antibody response.
UC-CH25Cervix carcinomaLiver and bonesPatient diagnosed with systemic lupus erythematosusPatient positive for anti-VEGF antibody response. Physician did not report any negative incidence on autoimmune disease.
UC-CH46Thyroid carcinomaLN and lungPatient that received CIGB-247 simultaneous with oral levothyroxinePatient positive for anti-VEGF antibody response.
UC-CQ116RCCLungPatient that received CIGB-247 simultaneous with recombinant IFN-α2bPatient positive for anti-VEGF antibody response.
UC-CQ111GBMPatient that received CIGB-247 simultaneous with RTPatient positive for anti-VEGF antibody response.
  1. aPatient positive for anti-VEGF antibody response is referred to subjects that showed at least one serum sample with antibodies specific to VEGF or with VEGF blocking activity detected during induction or re-immunization phases. ADC adenocarcinoma, QT chemotherapy, LN lymph nodes, RT radiotherapy, G-CSF granulocyte-colony stimulating factor, SCLC small cell lung cancer, GBM Glioblastoma multiforme, RCC Renal cell carcinoma, IFN Interferon