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Fig. 4 | BMC Immunology

Fig. 4

From: Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer

Fig. 4

B7-H6 positive staining according to the immunoreactive score in plasma cells infiltrating cervical intraepithelial lesions or invasive cancer. B7-H6 positivity in plasma cells is positively correlated with disease stage, confirmed by low staining in the intraepithelial lesion groups and stronger B7-H6 staining in the cancer groups. Statistically significant differences when comparing LSIL vs SCC (p = 0.001) and LSIL vs UCAC (p = 0.026) were found. As a control of non-abnormal or non-transformed cells, cervicitis specimens were also assessed. This group showed higher B7-H6 positive staining when compared against LSIL (p = 0.001). A positive correlation of B7-H6 staining between plasma cells and stage of the disease (LSIL, HSIL, and SCC) was found with ρ = 0.515 and a significance of p < 0.0005. Abbreviations: LSIL: low-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; SCC: squamous cervical carcinoma; UCAC: uterine cervical adenocarcinoma. ***p = 0.001, *p < 0.05

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