Skip to main content
Fig. 7 | BMC Immunology

Fig. 7

From: Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

Fig. 7

Protein association networks identify CXCR4-associated signaling components. (a). Distribution of node degrees in the co-expression network. 20 proteins with highest degree in knowledge based networks are highlighted. The dashed red line indicates median node degree. (b). Module sizes (of size ≥10) identified from the co-expression network (x-axis) across the top enriched pathway identified by the hypergeometric test (p ≤0.05) are shown. Text labels show -log 10 p-value from the hypergeometric test. The red bar indicates the only module with significantly different log2 fold change in 19% O2 vs 1% O2 and 19% O2 vs 1% O2 + CyA contrasts (p≤0.05, two-tailed t-test) (c). Distribution of log2 fold changes of the proteins (medians across three replicates) in the labeled module in 19% O2 vs 1% O2 and 19% O2 vs 1% O2 + CyA contrasts

Back to article page