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Table 1 Predicted B cell epitopes, their antigenicity, allergenicity and toxicity from spike S protein and orf1ab polyprotein

From: Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Protein Epitopea Start End Length Emini surface accessibility
Predictionb
Kolaskar & Tongaonkar antigenicity
Predictionc
Karplus & Schulz flexibility
Predictiond
Parker hydrophiliciy
Predictione
Vaxijen antigenicityf Allergenicity Toxicity
Spike S protein VYDPLQPE 1137 1144 8 1.923 1.082 Flexible 1.65 0.5148 Nonallergen Nontoxin
orf1ab SLDTYPSL 2297 2304 8 1173 1066 Flexible 1.25 0.6746 Nonallergen Nontoxin
KSVYYTSNP 1533 1541 9 308 1045 Flexible 2.833 0.6523 Nonallergen Nontoxin
DASGKPVPY 2924 2932 9 1632 1046 Flexible 3.178 0.6980 Nonallergen Nontoxin
VKGLQPSVGPKQ 6600 6611 12 1136 1066 Flexible 2.408 1.0641 Nonallergen Nontoxin
  1. aBepipred linear epitope prediction threshold for both proteins was 0.350
  2. bEmini surface accessibility prediction threshold for both proteins was 1.000
  3. cKolaskar & tongaonkar antigenicity prediction threshold for spike S protein and orf1ab was 1.041 and 1.044, respectively
  4. dKarplus & schulz flexibility prediction threshold for spike S protein and orf1ab was 0.993 and 0.988, respectively
  5. eParker hydrophiliciy prediction threshold for spike S protein and orf1ab was 1.238 and 1.127, respectively
  6. fVaxijen antigenicity threshold for both proteins was 0.4