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Table 4 Physical and chemical properties, antigenicity and number of the predicted transmembrane helices of SARS CoV-2 proteins

From: Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Viral protein Accession number Molecular weight (Dalton) Instability indexb Aliphatic index Theoretical pI No amino acids Extinction coefficient GRAVYc Vaxijen antigenicityd TMHs
orf1ab polyprotein YP_009724389.1 794,057.79 33.31 86.87 6.32 7096 942,275 −0.07 0.4624 14
orf1a polyprotein YP_009725295.1 489,988.91 34.92 88.99 6.04 4405 552,175 −0.023 0.4787 14
Surface glycoprotein YP_009724390.1 141,178.47 33.01 84.67 6.24 1273 148,960 −0.079 0.4646 1
orf3a protein YP_009724391.1 31,122.94 32.96 103.42 5.55 275 58,705 0.275 0.4945 3
Envelope protein YP_009724392.1 8365.04 38.68 144 8.57 75 6085 1.128 0.6025 1
Membrane glycoprotein YP_009724393.1 25,146.62 39.14 120.86 9.51 222 52,160 0.446 0.5102 3
orf6 protein YP_009724394.1 7272.54 31.16 130.98 4.6 61 8480 0.233 0.6131 0
aorf7a protein YP_009724395.1 13,744.17 48.66 100.74 8.23 121 7825 0.318 0.6441 1
orf7b protein YP_009725296.1 5180.27 50.96 156.51 4.17 43 7115 1.449 0.6025 1
orf8 protein YP_009724396.1 13,831.01 45.79 97.36 5.42 121 16,305 0.219 0.6502 0
Nucleocapsid phosphoprotein YP_009724397.2 45,625.7 55.09 52.53 10.07 419 43,890 −0.971 0.5059 0
aorf10 protein YP_009725255.1 4449.23 16.06 107.63 7.93 38 4470 0.637 0.7185 0
  1. THMs Transmembrane helices
  2. athe protein contains no tryptophan
  3. binstability index < 40 considered the protein stable
  4. cGRAVY negative sign indicated the protein is hydrophilic
  5. dthe threshold for the Vaxijen antigenicity is 0.4