Fig. 2

Effects of mutation of the putative transcriptional factor binding sites. a Promoter activities of mutant AP-1 sites were significantly decreased compared with wild-type controls. b Promoter activities of mutant NF-κB sites were more significantly decreased than wild controls. c Promoter activities of mutant Sp1–2 sites revealed a partially decreased change compared with wild-type controls; however, no significant differences were noted between mutant Sp1–1 sites and wild-type controls. All values are expressed as the mean ± SD and each experiment was conducted with triplicate cultures. The intergroup comparisons were performed using Student’s two-tailed unpaired t-test