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Fig. 5 | BMC Immunology

Fig. 5

From: Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Fig. 5

MyD88 is a master regulator upstream of two transcription factors with binding sites in the promotor regions of upregulated MyD88-dependent DEGs enriched in uptake processes. Ellipse nodes with black borders indicate transcription factors. MyD88, as a master regulator, is at the top of the network. Ellipse nodes with purple borders indicate genes that significantly enriched to uptake biological processes. The varying degree of red or blue hue in select nodes correlates with the gene’s Log2 Fold Change value. Red indicates positive fold change and blue indicates negative fold change. Gray nodes represent genes that were not differentially expressed. Green arrows indicate that the source node activates the target node. Red arrows indicate that the source node inhibits the target node. Black arrows indicate that the source node regulates the target node. Blue arrows are used to distinguish that the transcription factor source node has predicted binding sites in the promotor region of the target node

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