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Fig. 3 | BMC Immunology

Fig. 3

From: Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p

Fig. 3

CircFADS2 overexpression suppressed miR-15a-5p maturation in HBEpCs. Pearson’s correlation coefficient analysis was performed to analyze the correlation between expression levels of CircFADS2 and mature miR-15a-5p (a) or miR-15a-5p precursor (b) across plasma samples from sepsis patients (day 1). MiR-15a-5p precursor and mature miR-15a-5p were detected in the nuclei and cytoplasm, respectively (c), ***p < 0.001. CircFADS2 overexpression in circFADS2 expression vector transfected lung cells was confirmed RT-qPCR every 24 h until 96 h (d), *p < 0.05. Mature miR-15a-5p and miR-15a-5p precursor levels was measured to explore the role of circFADS2 miR-15a-5p maturation (e), *p < 0.05 compared to C or NC group

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BMC Immunology

ISSN: 1471-2172

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