Fig. 3

Glycyrrhizin regulates SIRT1 and STAT3 expression in vivo. a RT-PCR results showed that the mRNA expression of STAT3 was up-regulated while SIRT1 was down-regulated in human psoriasis skin tissues (N = 10) than normal skin tissues (N = 10). b western blotting results showed that compared with the skin tissues of IMD model, the protein expression of STAT3 was down-regulated while SIRT1 was up-regulated in Model+MTX or Model+GA group. c The immunohistochemical results showed that compared with normal subjects, the expression of STAT3 were substantially increased, and the expression of SIRT1 was substantially decreased, while the expression of AMPK was not substantially changed. d In IMD, the immunohistochemical results showed that when treated with glycyrrhizin, the expression of STAT3 was decreased while the expression of SIRT1 was increased in IMD. *P < 0.05, **P < 0.01 and ***P < 0.001