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Fig. 5 | BMC Immunology

Fig. 5

From: Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

Fig. 5

Glycyrrhizin suppresses the expression of STAT3 via SIRT1 in IL-17A-HaCaT cells. a The CCK-8 assay was used to determine the effect of EX527 and glycyrrhizin on proliferation of IL-17A-HaCaT cells. b The western blotting results show that EX527 promotes the expression of STAT3, p-STAT3, a-STAT3 in IL-17A-HaCaT cells, and glycyrrhizin can reverse the promotion of STAT3, p-STAT3 and a-STAT3 induced by EX527. c Histogram of western blotting statistical results. NOTES: Data are presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001; Con represents wild type HaCaT cells; GA represents glycyrrhizin; GAPDH is used for internal reference

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BMC Immunology

ISSN: 1471-2172

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