Fig. 6

Glycyrrhizin inhibits the expression of STAT3 by up-regulating SIRT1 in IL-17A-HaCaT cells. a and b By constructing SIRT1-knockdown small interfering RNA (a) and combining with CCK-8 experiments (b), we found that SIRT1-knockdown promoted the proliferation of IL-17- HaCaT cells. c When knock-down SIRT1 in IL-17- HaCaT cells, glycyrrhizin could reverse the promotion of STAT3, p-STAT3 and a-STAT3 induced by SIRT1 knock-down. d Histogram of western blotting statistical results. NOTES: Data are presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001; NC represents siRNA-NC transfected HaCaT cells; GA represents glycyrrhizin; GAPDH is used for internal reference