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Table 1 Clinical demographics of study subjects

From: Transcriptomics of type 2 diabetic and healthy human neutrophils

  

Healthy (N = 8)

Type 2 Diabetic (N = 13)

Total Cohort (N = 21*)

p-value

Age (mean in years ± SD)

 

39 (± 9.63)

58 (± 11.05)

51 (± 14.04)

0.007

Sex (no., %)

Male

4 (50%)

7 (53.85%)

11 (52.38%)

 

Female

4 (50%)

6 (46.15%)

10 (47.62%)

Ethnicity

Caucasian

5 (62.50%)

4 (30.77%)

9 (42.86%)

 

Hispanic

0

1 (7.69%)

1 (4.76%)

 

African-American

3 (37.50%)

8 (61.54%)

11 (52.38%)

Smoking Status (no., %)

Smokers

1 (12.50%)

1 (7.69%)

2 (9.52%)

 

Former Smokers

0

2 (15.38%)

2 (9.52%)

 

Never Smokers

7 (87.50%)

10 (76.92%)

17 (80.95%)

BMI (kg/m2; mean ± SD)

 

28.56 (± 4.47)

30.46 (± 6.27)

29.74 (± 5.61)

0.47

Blood Cholesterol (mg/dl; mean ± SD)

 

144.25 (± 20.61)

183.77 (± 66.97)

168.71 (± 56.80)

0.12

Blood Glucose (mg/dl; mean ± SD)

Normal (<  100 mg/dl)

96.50 (± 3.54)

96.50 (± 3.54)

 

Pre-diabetes (100-125 mg/dl)

107 (± 3.81)

107 (± 3.81)

 

Diabetes (> 126 mg/dl)

209

267.77 (± 123.38)

263.57 (± 119.58)

0.003

HbA1c % (mean ± SD)

Normal (<  5.7% HbA1c)

 

Pre-diabetes (5.7–6.4% HbA1c)

6.15 (± 0.17)

6.15 (± 0.17)

 

Diabetes (>  6.5% HbA1c)

9.64 (± 2.63)

9.64 (± 2.63)

Periodontal Condition (no., %)

Healthy

8 (100%)

0

8 (38.09%)

 

Mild

0

3 (23.08%)

3 (14.29%)

 

Moderate

0

6 (46.15%)

6 (28.57%)

 

Severe

0

2 (15.38%)

2 (9.52%)

 

Gingivitis

0

2 (15.38%)

2 (9.52%)

Neutrophil Count (mil. of cells, mean ± SD)

 

104.88 (± 57.23)

123.69 (± 65.68)

116.52 (± 61.83)

0.51

Monocyte Count (mil. of cells, mean ± SD)

 

72.50 (± 34.13)

99.59 (± 73.72)

89.27 (± 62.05)

0.34

  1. * N = 2 healthy and N = 1 diabetic subjects were included in both the serum and cell culture perturbation analyses. p-values calculated by unpaired t-tests (two-sided p-values; italicized p < 0.05 significant). SD standard deviation, BMI body-mass index