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Table 2 All statistically significant differentially expressed neutrophil genes comparing T2D (N = 11) vs. healthy (N = 7) subjects

From: Transcriptomics of type 2 diabetic and healthy human neutrophils

Gene Gene Name Annotated Role Log(FC) p-value FDR-corrected p-value
SLC9A4 solute carrier family 9 member A4 pH Regulation / Signaling −5.42 7.46E-08 0.001
NECTIN2 Nectin cell adhesion molecule 2 Immune −3.77 2.23E-07 0.002
PLPP3 phospholipid phosphatase 3 Lipids / Inflammation −5.37 3.38E-07 0.002
C3 complement C3 Inflammation / Immune −3.61 7.92E-07 0.003
IRAK2 interleukin-1 receptor-associated kinase 2 Inflammation / Immune −4.01 8.93E-07 0.003
KCNH4 potassium voltage-gated channel subfamily H member 4 Lipids / Insulin −4.41 9.15E-07 0.003
C1orf61 chromosome 1 open reading frame 61 Transcription −4.71 2.08E-06 0.005
CCRL2 C-C motif chemokine receptor like 2 Inflammation / Immune −3.37 2.61E-06 0.005
GNPDA1 glucosamine-6-phosphate deaminase 1 Glucose Metabolism −2.95 2.70E-06 0.005
CLIC4 chloride intracellular channel 4 Cell Processes −3.54 3.76E-06 0.007
GPR84 G protein-coupled receptor 84 Inflammation / Immune −3.41 4.09E-06 0.007
PLAU plasminogen activator, urokinase Immune / Blood −3.83 7.31E-06 0.01
SLC43A3 solute carrier family 43 member 3 Transmembrane Transport −3.34 1.04E-05 0.01
RHOV ras homolog family member V Cell Processes / Signaling −4.11 1.14E-05 0.01
SGPP2 sphingosine-1-phosphate phosphatase 2 Inflammation / Immune −3.42 1.19E-05 0.01
TNFAIP6 TNF alpha induced protein 6 Inflammation / Immune −3.01 1.69E-05 0.02
C15orf48 chromosome 15 open reading frame 48 Immune −4.01 1.84E-05 0.02
TLCD2 TLC domain containing 2 Lipids −1.60 2.28E-05 0.02
GTSCR1 Gilles de la Tourette syndrome chromosome region, candidate 1 -* 3.71 2.39E-05 0.02
SLC25A13 solute carrier family 25 member 13 Mitochondrial / Cell Processes −2.32 2.57E-05 0.02
RP11-1193F23.1 −2.68 2.68E-05 0.02
SPHK1 sphingosine kinase 1 Lipids / Inflammation −3.33 2.73E-05 0.02
DNAH17 dynein axonemal heavy chain 17 Motility (Sperm) −2.94 2.79E-05 0.02
SPATC1 spermatogenesis and centriole associated 1 −3.09 2.96E-05 0.02
RALGDS ral guanine nucleotide dissociation stimulator Cell Processes −2.69 3.01E-05 0.02
VEGFA vascular endothelial growth factor A Cell Growth / Angiogenesis / Lipids −2.01 3.05E-05 0.02
HTRA3 HtrA serine peptidase 3 Signaling / Binding −3.81 3.37E-05 0.02
CTB-114C7.4 −2.36 3.48E-05 0.02
MFSD2A major facilitator superfamily domain containing 2A Lipids / Transmembrane Transport (Brain) −2.96 3.88E-05 0.02
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Signaling (Brain) −2.61 3.90E-05 0.02
PNPLA1 patatin like phospholipase domain containing 1 Lipids −2.53 4.15E-05 0.02
ABCG1 ATP binding cassette subfamily G member 1 Inflammation / Immune / Lipids −1.45 4.28E-05 0.02
PTGES prostaglandin E synthase Inflammation / Lipids −3.13 4.46E-05 0.02
TBC1D30 TBC1 domain family member 30 Transport / GTPase −2.14 4.55E-05 0.02
GPR4 G protein-coupled receptor 4 Angiogenesis / Lipids −3.48 5.35E-05 0.03
CD300LD CD300 molecule like family member d Immune −2.41 5.97E-05 0.03
KLHDC8B kelch domain containing 8B Cell Processes / Mitosis −2.25 7.90E-05 0.04
ANKRD33B ankyrin repeat domain 33B −2.05 8.21E-05 0.04
LPCAT1 lysophosphatidylcholine acyltransferase 1 Lipids −1.86 8.31E-05 0.04
RP1-239B22.5 −3.87 9.27E-05 0.04
CTA-126B4.7 uncharacterized LOC101927344 −2.70 1.06E-04 0.05
TRAF3 TNF receptor associated factor 3 Immune −2.01 1.22E-04 0.05
LAMB3 laminin subunit beta 3 Cell Processes −3.02 1.23E-04 0.05
TTPAL alpha tocopherol transfer protein like −2.13 1.25E-04 0.05
TMEM231 transmembrane protein 231 Ciliogenesis −2.28 1.28E-04 0.05
AZIN1 antizyme inhibitor 1 Cell Growth / Homeostasis −1.90 1.30E-04 0.05
MARCH3 membrane associated ring-CH-type finger 3 Endosomal Transport −2.31 1.38E-04 0.05
LIMS1 LIM zinc finger domain containing 1 Cytoskeleton / Signaling −2.14 1.38E-04 0.05
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 Immune −3.55 1.41E-04 0.05
SQSTM1 sequestosome 1 Immune / Signaling −1.78 1.42E-04 0.05
  1. * - indicates no information available. FDR-corrected p-value < 0.05 (before rounding) considered significant. FC fold-change; FDR false discovery rate