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Table 4 The Top 30 of significant GO enrichment (biological process, molecular function, and cellular component) of differential expressed mRNAs

From: Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndrome

GO enrichment

Fold enrichment

Gene number

P value

GO domain

cellular ion homeostasis

18.832

3

0.009

Biological process

branching involved in labyrinthine layer morphogenesis

13.950

4

0.002

response to yeast

12.072

5

0.001

activation of transmembrane receptor protein tyrosine kinase activity

10.462

4

0.006

labyrinthine layer blood vessel development

8.260

5

0.003

positive regulation of cytokine production

7.847

6

0.001

negative regulation of viral genome replication

7.062

9

<0.001

chemokine-mediated signaling pathway

6.631

15

<0.001

regulation of angiogenesis

6.075

6

0.003

positive regulation of peptidyl-threonine phosphorylation

5.812

5

0.010

defense response to fungus

5.812

5

0.010

response to cold

5.231

6

0.005

cell maturation

5.231

6

0.005

cellular defense response

5.062

10

<0.001

positive regulation of angiogenesis

4.913

18

<0.001

calcium-mediated signaling

4.308

7

0.005

wound healing

3.923

10

0.001

type I interferon signaling pathway

3.923

8

0.004

positive regulation of protein kinase B signaling

3.737

10

0.001

cellular response to interleukin-1

3.537

8

0.007

immune response

2.908

39

<0.001

defense response to virus

2.853

15

0.001

chemotaxis

2.830

11

0.006

azurophil granule

11.667

4

0.004

Cellular component

collagen trimer

3.487

10

0.002

chemokine receptor activity

9.350

5

0.002

Molecular function

growth factor binding

5.887

5

0.010

chemokine activity

5.190

8

0.001

heparin binding

3.576

18

<0.001

receptor activity

2.930

20

<0.001