Fig. 3

Binding Affinity of Predicted Epitope Peptides to Target Genes (HHLA1,2 & 3 and MAGEB5) by HLA-DRB5 Immune variants: Each Immune variant was used at the NetMHCIIpan 3.0 to predict epitope peptides for each protein variant of the target genes. The plotted graphs showed gene-protein variants on the x-axis against and their different predicted epitope peptides represented by their peptide binding score on the y-axis and measured by their binding affinity; 1-log (IC50). A This figure shows the number of protein variants for HHLA1 (n = 2) and number of predicted unique epitope peptides (n = 3). The three epitope peptides were common to both protein variants. B This figure shows the number of protein variants for HHLA2 (n = 7) and number of unique predicted epitope peptides (n = 3) repeating in all protein variants. C This figure shows the number of protein variants for HHLA3 (n = 5) and number of unique predicted epitope peptides (n = 6) repeating in at least two protein variants. D This figure shows the number of protein variants for MAGEB5 (n = 1) and number of unique predicted epitope peptides (n = 3) with two of them (FLVVIFLKGNCANKE & QFLLYKFKMKQRILK) repeating due to different binding scores