Fig. 5

Statistical Analysis Representation of Genetic Association Between HHLA2 and MAGEB5: These figures are based on epitope prediction counts by HLA-C and HLA-DRB5 on protein variants from HHLA1, HHLA2, HHLA3 and MAGEB5. Analysis demonstrated a suggested genetic relationship between HHLA2 and MAGEB5, possible co-expression and co-evolution patterns in a given biological system. A This figure shows a regression analysis plot of positive correlation (Pearson correlation, p < 0.001) between HHLA2 and MAGEB5 epitope peptides predicted by HLA-C. B This figure shows the predicted model (HLA-C = HHLA2 + MAGEB5 + C), β = 0.21 (< 0), standard error, SE = 0.111 and p = 0.029. Only the variation of HHLA2 and the constant were statistically significant in the model. C) The predicted impact frequency of the various HLA-C immune variants used in the model were compared to those predicted HLA-DRB5. Though opposing effects were observed for relative immune variants, they weren’t comparable because they are different immune genes. D) The predicted model (HLA-DRB5 = HHLA2 + MAGEB5 + C) had the following parameters: β = 0.104, SE = 0.125 and p = 0.202, with equation: HLA-DRB5 = 0.104 (HHLA2) – 0.711 + 1.13. The variation for each of the targeted genes was not significantly important in impacting the model