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Table 1 Characteristics of the patients with Good's syndrome

From: Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

Characteristics Case 1 Case 2 Case 3 Case 4 Case 5
Age at diagnosis 43 54 (died in 2019) 55 (died in 2020) 70 (died in 2020) 57 (died in 2014)
Sex M M M F M
Operation time 2016 2015 None 2016 2003
Thymoma histology A AB B2 AB AB
B cells (5–18%) 3.1↓ 0.5↓ 0.6↓ 3.7↓ 4.4↓
T cells (60–79%) 93.4↑ 93.1↑ 88.3↑ 93.6↑ 87.8↑
CD4 + T cell (34–52%) 17.5↓ 13.7↓ 8.4%↓ 30.9↓ 32.1↓
CD8 + T cell (21–39%) 65.4↑ 63.5↑ 74.7%↑ 57.3↑ 49.8↑
IgG (7.0–16.0 g/L or 7.51–15.6 g/L) 0.51↓ 1.59↓ 1.34↓ 1.9↓ 0.82↓
IgA (0.7–4.0 g/L or 0.82–4.53 g/L)  < 0.0667↓  < 0.26↓ 0.25↓  < 0.0667↓ 0.13↓
IgM (0.4–2.3 g/L or 0.46–3.04 g/L) 0.15↓  < 0.17↓  < 0.17↓ 0.09↓ 0.08↓
Clinical symptoms Cough, expectoration, chest tightness, diarrhea Cough, expectoration, fever, diarrhea Skin and mucosal abscesses, cough, dyspnea Cough, diarrhea, abdominal discomfort Fever, cough
Main location of infection Respiratory tract Respiratory tract Respiratory tract Respiratory tract, intestinal tract Respiratory tract
Severity of infection Mild Severe Severe Mild to Severe Severe
Main comorbiditiesa Bronchiectasis, pneumonia Pneumonia, bronchiectasis, COPD, ARDS, respiratory failure Pericardial placeholder, COPD, interstitial pneumonia Oral lichen planus, intestinal infection, urinary tract infection Interstitial pneumonia, pulmonary tuberculosis
Pathogenb C. difficile CMV, RuV, CVB, Aspergillus, SPn, ECl, Cal, Aba CMV, Pc CMV, Hp Cal, TB
Treatmentc IVIG, Antibiotic IVIG, ALB, Antibiotic, Antifungal, Methylprednisolone IVIG, Antibiotic, Methylprednisolone IVIG, ALB, Antibiotic IVIG, Antibiotic, Methylprednisolone, Antiviral
Radiotherapy No No Yes No Yes
Chemotherapy No No Yes No No
Live status Survived Died Died Died Died
Cause of death None Lung infection, coronary heart disease Lung infection Severe pneumonia, septic shock and respiratory failure Septic shock, multiple organ failure
  1. Note: B cells, CD4+ T cells, IgG, IgA, and IgM had the lowest test results. T cells and CD8+ T cells had the highest test results
  2. aCOPD: chronic obstructive pulmonary disease; ARDS: acute respiratory distress syndrome
  3. bC. difficile: Clostridium difficile; CMV: cytomegalovirus; RuV: rubella virus; CVB: Coxsackie virus; SPn: Streptococcus pneumonia; ECl: Enterobacter cloacae; Cal: Candida albicans; Aba: Acinetobacter baumannii; Pc: Pneumocystis carinii; Hp: Helicobacter pylori; TB: Tubercle bacillus
  4. cIVIG: Intravenous immunoglobulin; ALB: Intravenous albumin