Characteristics | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
---|---|---|---|---|---|
Age at diagnosis | 43 | 54 (died in 2019) | 55 (died in 2020) | 70 (died in 2020) | 57 (died in 2014) |
Sex | M | M | M | F | M |
Operation time | 2016 | 2015 | None | 2016 | 2003 |
Thymoma histology | A | AB | B2 | AB | AB |
B cells (5–18%) | 3.1↓ | 0.5↓ | 0.6↓ | 3.7↓ | 4.4↓ |
T cells (60–79%) | 93.4↑ | 93.1↑ | 88.3↑ | 93.6↑ | 87.8↑ |
CD4 + T cell (34–52%) | 17.5↓ | 13.7↓ | 8.4%↓ | 30.9↓ | 32.1↓ |
CD8 + T cell (21–39%) | 65.4↑ | 63.5↑ | 74.7%↑ | 57.3↑ | 49.8↑ |
IgG (7.0–16.0 g/L or 7.51–15.6 g/L) | 0.51↓ | 1.59↓ | 1.34↓ | 1.9↓ | 0.82↓ |
IgA (0.7–4.0 g/L or 0.82–4.53 g/L) | < 0.0667↓ | < 0.26↓ | 0.25↓ | < 0.0667↓ | 0.13↓ |
IgM (0.4–2.3 g/L or 0.46–3.04 g/L) | 0.15↓ | < 0.17↓ | < 0.17↓ | 0.09↓ | 0.08↓ |
Clinical symptoms | Cough, expectoration, chest tightness, diarrhea | Cough, expectoration, fever, diarrhea | Skin and mucosal abscesses, cough, dyspnea | Cough, diarrhea, abdominal discomfort | Fever, cough |
Main location of infection | Respiratory tract | Respiratory tract | Respiratory tract | Respiratory tract, intestinal tract | Respiratory tract |
Severity of infection | Mild | Severe | Severe | Mild to Severe | Severe |
Main comorbiditiesa | Bronchiectasis, pneumonia | Pneumonia, bronchiectasis, COPD, ARDS, respiratory failure | Pericardial placeholder, COPD, interstitial pneumonia | Oral lichen planus, intestinal infection, urinary tract infection | Interstitial pneumonia, pulmonary tuberculosis |
Pathogenb | C. difficile | CMV, RuV, CVB, Aspergillus, SPn, ECl, Cal, Aba | CMV, Pc | CMV, Hp | Cal, TB |
Treatmentc | IVIG, Antibiotic | IVIG, ALB, Antibiotic, Antifungal, Methylprednisolone | IVIG, Antibiotic, Methylprednisolone | IVIG, ALB, Antibiotic | IVIG, Antibiotic, Methylprednisolone, Antiviral |
Radiotherapy | No | No | Yes | No | Yes |
Chemotherapy | No | No | Yes | No | No |
Live status | Survived | Died | Died | Died | Died |
Cause of death | None | Lung infection, coronary heart disease | Lung infection | Severe pneumonia, septic shock and respiratory failure | Septic shock, multiple organ failure |