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Table 1 Characteristics of the patients with Good's syndrome

From: Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

Characteristics

Case 1

Case 2

Case 3

Case 4

Case 5

Age at diagnosis

43

54 (died in 2019)

55 (died in 2020)

70 (died in 2020)

57 (died in 2014)

Sex

M

M

M

F

M

Operation time

2016

2015

None

2016

2003

Thymoma histology

A

AB

B2

AB

AB

B cells (5–18%)

3.1↓

0.5↓

0.6↓

3.7↓

4.4↓

T cells (60–79%)

93.4↑

93.1↑

88.3↑

93.6↑

87.8↑

CD4 + T cell (34–52%)

17.5↓

13.7↓

8.4%↓

30.9↓

32.1↓

CD8 + T cell (21–39%)

65.4↑

63.5↑

74.7%↑

57.3↑

49.8↑

IgG (7.0–16.0 g/L or 7.51–15.6 g/L)

0.51↓

1.59↓

1.34↓

1.9↓

0.82↓

IgA (0.7–4.0 g/L or 0.82–4.53 g/L)

 < 0.0667↓

 < 0.26↓

0.25↓

 < 0.0667↓

0.13↓

IgM (0.4–2.3 g/L or 0.46–3.04 g/L)

0.15↓

 < 0.17↓

 < 0.17↓

0.09↓

0.08↓

Clinical symptoms

Cough, expectoration, chest tightness, diarrhea

Cough, expectoration, fever, diarrhea

Skin and mucosal abscesses, cough, dyspnea

Cough, diarrhea, abdominal discomfort

Fever, cough

Main location of infection

Respiratory tract

Respiratory tract

Respiratory tract

Respiratory tract, intestinal tract

Respiratory tract

Severity of infection

Mild

Severe

Severe

Mild to Severe

Severe

Main comorbiditiesa

Bronchiectasis, pneumonia

Pneumonia, bronchiectasis, COPD, ARDS, respiratory failure

Pericardial placeholder, COPD, interstitial pneumonia

Oral lichen planus, intestinal infection, urinary tract infection

Interstitial pneumonia, pulmonary tuberculosis

Pathogenb

C. difficile

CMV, RuV, CVB, Aspergillus, SPn, ECl, Cal, Aba

CMV, Pc

CMV, Hp

Cal, TB

Treatmentc

IVIG, Antibiotic

IVIG, ALB, Antibiotic, Antifungal, Methylprednisolone

IVIG, Antibiotic, Methylprednisolone

IVIG, ALB, Antibiotic

IVIG, Antibiotic, Methylprednisolone, Antiviral

Radiotherapy

No

No

Yes

No

Yes

Chemotherapy

No

No

Yes

No

No

Live status

Survived

Died

Died

Died

Died

Cause of death

None

Lung infection, coronary heart disease

Lung infection

Severe pneumonia, septic shock and respiratory failure

Septic shock, multiple organ failure

  1. Note: B cells, CD4+ T cells, IgG, IgA, and IgM had the lowest test results. T cells and CD8+ T cells had the highest test results
  2. aCOPD: chronic obstructive pulmonary disease; ARDS: acute respiratory distress syndrome
  3. bC. difficile: Clostridium difficile; CMV: cytomegalovirus; RuV: rubella virus; CVB: Coxsackie virus; SPn: Streptococcus pneumonia; ECl: Enterobacter cloacae; Cal: Candida albicans; Aba: Acinetobacter baumannii; Pc: Pneumocystis carinii; Hp: Helicobacter pylori; TB: Tubercle bacillus
  4. cIVIG: Intravenous immunoglobulin; ALB: Intravenous albumin