Fig. 2

IFN-γR1 detection and IFN-γ signalling in CD14 + monocytes in control and suspected MSMD patients. PID01, who has a known mutation in IFNGR1 (c.818del4), had elevated levels of IFN-γR1 expression, but decreased levels of IFN-γ signalling (fold-change in pSTAT1 detection following stimulation with IFN-γ) compared to the controls. Other patients for whom variants have been identified in IFN-γR are also shown in the figure—these suspected MSMD patients showed varying degrees of IFN-γR1 expression and IFN-γ signalling