Fig. 5

Comparison of distribution of fold changes in pSTATs for controls (n = 10) and patients. A Fold change in pSTAT1, i.e. IFN-γ signalling, for controls and patients in various cell subsets. pSTAT1 was measured for both unstimulated and IFN-γ (100 ng/mL) stimulated PBMCs; B Fold change in pSTAT4, i.e. IL-12 signalling, for controls and patients in various cell subsets. pSTAT4 was measured on PHA pre-stimulated PBMCs that were then either left unstimulated or stimulated with IL-12 (100 ng/mL). There were no significant differences in cytokine signalling between the controls and the patient group, however, the patient results should rather be considered on a case-by-case manner due to the diversity in clinical presentation of the patients