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Table 2 Humoral responses against pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) (mean ± SEM)

From: Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model

  Negative control Positive control GC3111 Enhanced GC3111
Anti-PT IgG (U/mL)
 Naïve (N = 5) 0.86 ± 0.17 0.55 ± 0.16 0.66 ± 0.16 0.82 ± 0.31
 1w before booster vaccination (n = 6) 0 9,804.25 ± 1,061.82 8,102.17 ± 1,002.83 10,608.92 ± 2,022.17
 2w after booster vaccination (N = 10) 92.20 ± 63.98 15,457.80 ± 1,781.44 11,734.00 ± 886.59 16,580.25 ± 1,663.38
 4w after booster vaccination (N = 10) 0 22,270.00 ± 3,286.30 19,936.00 ± 2,972.66 19,203.90 ± 3,494.35
Anti-FHA IgG (U/mL)
 Naïve (N = 5) 0.01 0 0 0.02 ± 0.01
 1w before booster vaccination (N = 6) 0.88 ± 0.22 51.41 ± 9.98 48.39 ± 11.00 40.74 ± 7.85
 2w after booster vaccination (N = 10) 0 117.70 ± 17.95 73.10 ± 15.04 93.90 ± 16.80
 4w after booster vaccination (N = 10) 7.50 ± 3.84 78.00 ± 8.79 60.50 ± 3.45 62.00 ± 6.35
Anti-PRN IgG (U/mL)
 Naïve (N = 5) 0 0 0 0
 1w before booster vaccination (N = 6) 2.88 ± 2.80 510.42 ± 42.25 436.08 ± 38.92 456.75 ± 52.19
 2w after booster vaccination (N = 10) 96.40 ± 96.40 2,181.00 ± 225.35 2,629.10 ± 272.59 2,686.10 ± 320.84
 4w after booster vaccination (N = 10) 18.90 ± 18.90 1,491.50 ± 127.52 2,101.40 ± 73.77 1,918.10 ± 237.37
  1. SEM = standard errors of the means