Skip to main content

Table 3 Univariate and multivariate logistic regression analysis of related factors of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA)

From: Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis

  Univariate logistic analysis Multivariate logistic analysis
OR (95% CI) P value OR (95% CI) P value
sPD-1 1.00 (1.00–1.01) 0.008* 1.012 (1.002–1.023) 0.020*
Age 1.05 (0.99–1.10) 0.073   
Female 0.27 (0.08–0.88) 0.029* 0.135 (0.005–3.981) 0.246
Disease duration 1.00 (0.95–1.06) 0.977   
Smoking history 9.77 (1.22–78.14) 0.032* 2.35 (0.042–130.83) 0.677
DAS28-ESR 1.05 (0.77–1.44) 0.768   
Sharp score 0.86 (0.69–1.07) 0.171   
Anti-CCP positive 8.75 (1.69–45.44) 0.029* 10.601 (0.602–186.681) 0.107
Anti-CCP titer 1.00 (1.00–1.01) 0.014* 1.001 (0.999–1.003) 0.587
RF positive 1.94 (0.59–6.41) 0.278   
RF titer 1.00 (0.99–1.01) 0.175   
Ferritin 1.00 (0.99–1.01) 0.641   
Use of biologics 5.71 (0.70–47.01) 0.105   
Use of MTX 0.13 (0.05–0.34) < 0.0001* 0.052 (0.009–0.292) 0.0008*
Use of GCs 2.61 (1.01–6.73) 0.047* 6.517 (0.588–72.206) 0.127
Dose of GCs 1.06 (1.01–1.12) 0.021* 1.024 (0.927–1.131) 0.637
  1. sPD-1 soluble programmed death molecule-1, DAS28 disease activity score using 28 joint counts, anti-CCP anticitrullinated peptide antibody, RF rheumatoid factor, MTX methotrexate, GCs glucocorticoids (in prednisolone equivalent)
  2. –: NA; *P < 0.05