Natural immunogenic properties of bioinformatically predicted linear B-cell epitopes of dengue envelope and pre-membrane proteins

Table 2 Percentage positive antibody responses of sera for peptides that represent prM protein epitopes with a pan serotype conservancy > 50%

Peptide ID (location)	Sera infected with one serotype				Sera infected with two serotypes
Peptide ID (location)	DENV1 serotype	DENV2 serotype	DENV3 serotype	DENV4 serotype	Sera infected with two serotypes
P1/prM (1–16)	12 100%	12 100%	12 100%	12 100%	5 42%
P2/prM (15–31)	0 0%	0 0%	0 0%	0 0%	0 0%
P3/prM (43–57)	0 0%	0 0%	0 0%	0 0%	0 0%
P4/prM (55–74)	0 0%	1 8%	0 0%	0 0%	0 0%
P5/prM (73–90)	0 0%	0 0%	0 0%	0 0%	0 0%
P6/prM (88–107)	0 0%	0 0%	0 0%	12 100%	3 25%
P7/prM (102–119)	12 100%	12 100%	12 100%	12 100%	8 67%
P8/prM (126–142)	0 0%	0 0%	2 17%	0 0%	0 0%

Number of sera samples giving positive responses out of twelve sera samples tested per serotype (DENV1, DENV2, DENV3, DENV4), and its percentage (%) are shown. The number of total tested sera samples infected with two serotypes are also twelve. The corresponding epitope/peptide sequences from cross serotypes are based on the peptide arrays; DENV2 (New Guinea C (NR-506))

ISSN: 1471-2172