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Table 3 The antibody responses of the four representative DENV peptides of E protein epitopes with less than 50% pan serotype conservancy

From: Natural immunogenic properties of bioinformatically predicted linear B-cell epitopes of dengue envelope and pre-membrane proteins

Epitope ID/peptide ID   Serotype of sera % Sensitivity % Specificity
DENV1 DENV2 DENV3 DENV4
EP4/E DENV1 0
0%
0
0%
0
0%
0
0%
0 100
DENV2 0
0%
0
0%
0
0%
0
0%
0 100
DENV3 1
8%
0
0%
2
17%
0
0%
17 97.2
DENV4 0
0%
1
8%
0
0%
4
33%
33 97.2
EP8/E DENV1 10
83%
2
17%
5
42%
1
8%
83 77.8
DENV2 5
42%
4
33%
0
0%
2
17%
33 80
DENV3 8
67%
1
8%
8
67%
0
0%
67 75
DENV4 0
0%
0
0%
0
0%
0
0%
0 100
EP9/E DENV1 0
0%
0
0%
0
0%
0
0%
0 100
DENV2 0
0%
0
0%
0
0%
0
0%
0 100
DENV3 0
0%
0
0%
0
0%
0
0%
0 100
DENV4 0
0%
0
0%
0
0%
0
0%
0 100
EP11-12/E DENV1 10
83%
0
0%
1
8%
0
0%
83 97.2
DENV2 0
0%
10
83%
0
0%
0
0%
83 100
DENV3 0
0%
2
17%
5
42%
3
25%
42 86
DENV4 0
0%
0
0%
4
33%
4
33%
33 89
EP14/E DENV1 2
17%
0
0%
0
0%
1
8%
17 97.2
DENV2 2
17%
12
100%
12
100%
0
0%
100 61
DENV3 0
0%
10
83%
11
92%
0
0%
92 72
DENV4 0
0%
0
0%
0
0%
11
92%
92 100
EP17/E DENV1 3
25%
1
8%
4
33%
1
8%
25 83
DENV2 0
0%
6
50%
0
0%
5
42%
50 86
DENV3 0
0%
1
8%
10
83%
4
33%
83 86
DENV4 0
0%
1
8%
10
83%
4
33%
33 30
EP20/E DENV1 12
100%
0
0%
0
0%
0
0%
100 100
DENV2 0
0%
8
67%
0
0%
1
8%
67 97.2
DENV3 2
17%
0
0%
11
92%
0
0%
92 94.4
DENV4 0
0%
0
0%
0
0%
10
83%
83 100
EP21/E DENV1 2
17%
0
0%
0
0%
0
0%
17 100
DENV2 0
0%
0
0%
0
0%
0
0%
0 100
DENV3 0
0%
0
0%
0
0%
0
0%
0 100
DENV4 0
0%
0
0%
0
0%
0
0%
0 100
EP22-23/E DENV1 4
33%
0
0%
3
25%
0
0%
33 91.6
DENV2 0
0%
6
50%
4
33%
1
8%
50 86
DENV3 1
8%
0
0%
10
83%
2
17%
83 91.6
DENV4 0
0%
1
8%
1
8%
8
67%
67 94.4
EP25/E DENV1 10
83%
5
42%
12
100%
1
8%
83 50
DENV2 0
0%
7
58%
1
8%
8
67%
58 75
DENV3 2
17%
9
75%
12
100%
2
17%
100 63.8
DENV4 9
75%
4
33%
3
25%
12
100%
100 55.5
EP30/E
(first half of the epitope)
DENV1 5
42%
2
17%
7
58%
1
8%
47 72.2
DENV2 12
100%
12
100%
12
100%
12
100%
100 0
DENV3 12
100%
12
100%
12
100%
12
100%
100 0
DENV4 12
100%
11
92%
10
83%
12
100%
100 8.3
EP30/E
(latter half of the epitope)
DENV1 0
0%
0
0%
0
0%
0
0%
0 100
DENV2 0
0%
0
0%
0
0%
0
0%
0 100
DENV3 0
0%
0
0%
0
0%
0
0%
0 100
DENV4 0
0%
0
0%
0
0%
0
0%
0 100
  1. Number of sera samples giving positive responses out of 12 sera samples tested per serotype (DENV1, DENV2, DENV3, DENV4), and its percentage (%) are shown. The corresponding epitope/peptide sequences from cross serotypes are based on the peptide arrays; DENV1 (Singapore/S275/1990 (NR-4551), DENV2 (New Guinea C (NR-507), DENV3 (Sleman/1978 (NR-511)), DENV4 (Dominica/814669/1981 (NR-512)