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Table 3 The antibody responses of the four representative DENV peptides of E protein epitopes with less than 50% pan serotype conservancy

From: Natural immunogenic properties of bioinformatically predicted linear B-cell epitopes of dengue envelope and pre-membrane proteins

Epitope ID/peptide ID   Serotype of sera % Sensitivity % Specificity
DENV1 DENV2 DENV3 DENV4
EP4/E DENV1 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV2 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV3 1
8% 		0
0% 		2
17% 		0
0% 		17 97.2
DENV4 0
0% 		1
8% 		0
0% 		4
33% 		33 97.2
EP8/E DENV1 10
83% 		2
17% 		5
42% 		1
8% 		83 77.8
DENV2 5
42% 		4
33% 		0
0% 		2
17% 		33 80
DENV3 8
67% 		1
8% 		8
67% 		0
0% 		67 75
DENV4 0
0% 		0
0% 		0
0% 		0
0% 		0 100
EP9/E DENV1 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV2 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV3 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV4 0
0% 		0
0% 		0
0% 		0
0% 		0 100
EP11-12/E DENV1 10
83% 		0
0% 		1
8% 		0
0% 		83 97.2
DENV2 0
0% 		10
83% 		0
0% 		0
0% 		83 100
DENV3 0
0% 		2
17% 		5
42% 		3
25% 		42 86
DENV4 0
0% 		0
0% 		4
33% 		4
33% 		33 89
EP14/E DENV1 2
17% 		0
0% 		0
0% 		1
8% 		17 97.2
DENV2 2
17% 		12
100% 		12
100% 		0
0% 		100 61
DENV3 0
0% 		10
83% 		11
92% 		0
0% 		92 72
DENV4 0
0% 		0
0% 		0
0% 		11
92% 		92 100
EP17/E DENV1 3
25% 		1
8% 		4
33% 		1
8% 		25 83
DENV2 0
0% 		6
50% 		0
0% 		5
42% 		50 86
DENV3 0
0% 		1
8% 		10
83% 		4
33% 		83 86
DENV4 0
0% 		1
8% 		10
83% 		4
33% 		33 30
EP20/E DENV1 12
100% 		0
0% 		0
0% 		0
0% 		100 100
DENV2 0
0% 		8
67% 		0
0% 		1
8% 		67 97.2
DENV3 2
17% 		0
0% 		11
92% 		0
0% 		92 94.4
DENV4 0
0% 		0
0% 		0
0% 		10
83% 		83 100
EP21/E DENV1 2
17% 		0
0% 		0
0% 		0
0% 		17 100
DENV2 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV3 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV4 0
0% 		0
0% 		0
0% 		0
0% 		0 100
EP22-23/E DENV1 4
33% 		0
0% 		3
25% 		0
0% 		33 91.6
DENV2 0
0% 		6
50% 		4
33% 		1
8% 		50 86
DENV3 1
8% 		0
0% 		10
83% 		2
17% 		83 91.6
DENV4 0
0% 		1
8% 		1
8% 		8
67% 		67 94.4
EP25/E DENV1 10
83% 		5
42% 		12
100% 		1
8% 		83 50
DENV2 0
0% 		7
58% 		1
8% 		8
67% 		58 75
DENV3 2
17% 		9
75% 		12
100% 		2
17% 		100 63.8
DENV4 9
75% 		4
33% 		3
25% 		12
100% 		100 55.5
EP30/E
(first half of the epitope) 		DENV1 5
42% 		2
17% 		7
58% 		1
8% 		47 72.2
DENV2 12
100% 		12
100% 		12
100% 		12
100% 		100 0
DENV3 12
100% 		12
100% 		12
100% 		12
100% 		100 0
DENV4 12
100% 		11
92% 		10
83% 		12
100% 		100 8.3
EP30/E
(latter half of the epitope) 		DENV1 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV2 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV3 0
0% 		0
0% 		0
0% 		0
0% 		0 100
DENV4 0
0% 		0
0% 		0
0% 		0
0% 		0 100
  1. Number of sera samples giving positive responses out of 12 sera samples tested per serotype (DENV1, DENV2, DENV3, DENV4), and its percentage (%) are shown. The corresponding epitope/peptide sequences from cross serotypes are based on the peptide arrays; DENV1 (Singapore/S275/1990 (NR-4551), DENV2 (New Guinea C (NR-507), DENV3 (Sleman/1978 (NR-511)), DENV4 (Dominica/814669/1981 (NR-512)
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BMC Immunology

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