Fig. 5

TFAM-regulated alternative splicing of the transcript factors are strongly linked to the TFAM-repressed gene expression. a Venn diagram shows the overlap of the DNA motifs enriched in the promoter regions of the TFAM-regulated genes. The overlap was performed among the motifs over-represented in the DNA regions that were 1 K, 2 K, and 3 K upstream and downstream from the transcription start sites. b Overlap of the DNA binding motifs of TFAM-regulated TFs (RASGs) with the DNA motifs enriched in the promoter regions of the TFAM-repressed genes (DEGs). c Venn diagram shows the overlap among the down-DEGs containing the DNA binding motifs for the top four TFs (NFIB, USF2, TEAD2, and NFE2L1) that were ranked by the number of down-DEGs harboring their DNA binding sites. d Overlap of genes that engage multiple functions. e Networks between the TFAM-regulated TFs and their targeted down-DEGs involved in the interferon/cytokine-mediated signaling pathways, immune/innate immune response, response/defense response to virus. The down-DEGs were grouped based on whether they are specific to each of the three classes of functions