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Fig. 7 | BMC Immunology

Fig. 7

From: Transmembrane signaling molecules play a key role in the pathogenesis of IgA nephropathy: a weighted gene co-expression network analysis study

Fig. 7

PPI network construction and hub gene selection. A The constructed PPI network for all the genes in modules. B Top 30 genes of each module based on module membership values (kME > 0.8). C 16 identified hub genes. Colors representing the module colors (D). 11 validated hub genes (true hub genes) using the highly correlated genes based on gene significance (GS) and module membership (MM) values. Hub genes were the ones among both the top 5% of genes in each module in the PPI network (based on degree centrality) and top 30 genes ranked by kME value. The constructed PPI network is accessible at network data exchange (NDEx) server by clicking on the URL: “https://public.ndexbio.org/#/network/5c60dee6-66dd-11eb-9e72-0ac135e8bacf?accesskey=7af2e78864f10bfa6107789793d7581214d6c1485e4cd566975fbe8df4469a30

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