| SLE | OADs | Healthy controls | p value |
---|
(n = 90) | (n = 56) | (n = 100) |
---|
Sex (females/males) | 83/7 | 44/12 | 87/13 | 0.058a |
Positive IgG ANAs (%) | 100% (90/90) | 57% (32/56) | 3% (3/100) | < 0.001a |
Positive HA IgG ANA (%) | 71% (64/90) | 30% (17/56) | 0 | < 0.001a |
| P50 (P25-P75) | P50 (P25-P75) | P50 (P25-P75) | |
Age (years) | 34 (27–45) | 37(31–46) | 33 (28–44) | 0.071a |
SLEDAI score | 14 (10–18) | ND | ND | |
CXCL1 (pg/mL)c | 1492.86 (735.47–2887.34) | 174.23 (17.07–368.40) | 13.58 (8.46–37.22) | < 0.001b |
An-dsDNA IgG (IU/L)d | 1093.37 (448.21–2215.30) | 10 (10–10) | 10 (10–10) | < 0.001b |
C3 (g/L)e | 0.54 (0.34–0.77) | 1.04 (0.86–1.27) | 1.09 (0.96–1.23) | < 0.001b |
C4 (g/L)f | 0.09 (0.04–0.12) | 0.21 (0.15–0.30) | 0.255 (0.21–0.30) | < 0.001b |
ESR (mm/h)g | 25.45 (18.13–54.48) | 19.5 (10.7–37.3) | 12.75 (7.7–21.43) | < 0.001b |
CRP (mg/mL)h | 1.66 (0.67–5.49) | 2.31 (0.92–8.20) | 0.44 (0.30–0.57) | < 0.001b |
Albumin (g/L)i | 37.65 (30.88–42.80) | 41.3 (35.55–44.53) | 45.0 (43.30–46.60) | < 0.001b |
Neu (×109)j | 3.73 (2.60–5.65) | 3.29 (2.47–5.03) | 3.23 (2.55–4.0) | 0.030b |
- Characteristics of the study populations were shown in Table 1. SLE: Systemic lupus erythematosus; OADs: other autoimmune diseases; HAIgGANA: high-avidity antinuclear antibody (ANA) of the IgG isotype; ND: not detected. SLEDAI: SLE Disease Activity Index; C3/C4: Complement 3/4; ESR: erythrocyte sedimentation ratio; CRP: C-reactive protein; Neu: neutrophils
- aData was compared to different groups, the difference was statistically significant. The chi-squared test or Fisher's exact test were used
- bData was compared to different groups, the difference was statistically significant. The Kruskal–Wallis H test were used
- CSLE versus healthy controls, p < 0.001; SLE versus OAD, p < 0.001; OAD versus healthy controls, p < 0.001
- dSLE versus healthy controls, p < 0.001; SLE versus OAD, p < 0.001; OAD versus healthy controls, p = 0.002
- eSLE versus healthy controls, p < 0.001; SLE versus OAD, p < 0.001; OAD versus healthy controls, p = 0.011
- fSLE versus healthy controls, p < 0.001; SLE versus OAD, p < 0.001; OAD versus healthy controls, p = 0.007
- gSLE versus healthy controls, p < 0.001; SLE versus OAD, p = 0.158; OAD versus healthy controls, p < 0.001
- hSLE versus healthy controls, p < 0.001; SLE versus OAD, p = 0.094; OAD versus healthy controls, p < 0.001
- iSLE versus healthy controls, p < 0.001; SLE versus OAD, p = 0.005; OAD versus healthy controls, p < 0.001
- jSLE versus healthy controls, p = 0.007; SLE versus OAD, p = 0.352; OAD versus healthy controls, p = 0.242