- In SFMCs cultured for 48Â h, 10-NO2-OA decreased the secretion of bioactive type I interferons and MCP-1 but not MMP3. In SFMCs cultured for 21Â days, 10-NO2-OA decreased the production of MCP-1 but not TRAP. In co-cultures of FLSs and PBMCs, 10-NO2-OA decreased the production of MCP-1 but not MMP3