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Table 1 Correlation analysis between FNBP1 and relate genes and markers of immune cells in TIMER

From: Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD

Description

Gene markers

BRCA (n = 1100)

LUAD (n = 515)

STAD (n = 415)

None

Purity

None

Purity

None

Purity

Cor

P

Cor

P

Cor

P

Cor

P

Cor

P

Cor

P

CD8+ T cell

CD8A

0.498

***

0.423

***

0.527

***

0.453

***

0.492

***

0.481

***

 

CD8B

0.407

***

0.315

***

0.398

***

0.316

***

0.404

***

0.407

***

T cell(general)

CD2

0.513

***

0.424

***

0.594

***

0.524

***

0.512

***

0.501

***

 

CD3D

0.452

***

0.349

***

0.501

***

0.405

***

0.477

***

0.461

***

 

CD3E

0.503

***

0.415

***

0.608

***

0.544

***

0.507

***

0.496

***

B cell

CD19

0.355

***

0.244

***

0.416

***

0.316

***

0.552

***

0.536

***

 

CD79A

0.370

***

0.259

***

0.359

***

0.257

***

0.517

***

0.487

***

Monocyte

CD115(CSF1R)

0.451

***

0.369

***

0.608

***

0.551

***

0.566

***

0.550

***

 

CD86

0.444

***

0.364

***

0.557

***

0.484

***

0.440

***

0.424

***

TAM

CCL2

0.333

***

0.237

***

0.344

***

0.261

***

0.472

***

0.464

***

 

CD68

0.380

***

0.301

***

0.424

***

0.356

***

0.213

***

0.206

**

 

IL10

0.390

***

0.315

***

0.411

***

0.320

***

0.429

***

0.424

***

M1 Macrophage

COX2(PTGS2)

0.253

***

0.165

***

0.003

0.952

− 0.002

0.963

0.078

0.142

0.064

0.260

 

INOS(NOS2)

0.110

**

0.116

**

0.176

**

0.102

0.036

− 0.037

0.489

− 0.049

0.399

 

IRF5

0.252

***

0.198

***

0.488

***

0.418

***

0.338

***

0.340

***

M2 Macrophage

CD163

0.397

***

0.338

***

0.531

***

0.467

***

0.454

***

0.447

***

 

MS4A4A

0.406

***

0.326

***

0.434

***

0.355

***

0.496

***

0.486

***

 

VSIG4

0.300

***

0.216

***

0.389

***

0.320

***

0.410

***

0.409

***

Neutrophils

CCR7

0.470

***

0.385

***

0.559

***

0.486

***

0.632

***

0.621

***

 

CD11b(ITGAM)

0.453

***

0.377

***

0.554

***

0.501

***

0.514

***

0.511

***

 

CD66b(CEACAM8)

0.015

0.643

0.022

0.527

0.107

0.020

0.096

0.044

0.035

0.514

0.034

0.538

Natural killer cell

KIR2DL1

0.241

***

0.181

***

0.217

***

0.183

***

0.192

**

0.170

*

 

KIR2DL3

0.278

***

0.210

***

0.287

***

0.234

***

0.134

*

0.100

0.072

 

KIR2DL4

0.282

***

0.209

***

0.292

***

0.228

***

0.034

0.525

0.007

0.911

 

KIR2DS4

0.240

***

0.183

***

0.282

***

0.231

***

0.152

*

0.132

0.017

 

KIR3DL1

0.291

***

0.224

***

0.248

***

0.199

***

0.217

***

0.209

***

 

KIR3DL2

0.332

***

0.255

***

0.323

***

0.259

***

0.302

***

0.291

***

 

KIR3DL3

0.196

***

0.163

***

0.109

0.020

0.090

0.065

− 0.054

0.307

− 0.055

0.335

Dendritic cell

BDCA-1(CD1C)

0.416

***

0.311

***

0.291

***

0.218

***

0.623

***

0.622

***

 

BDCA-4(NRP1)

0.376

***

0.296

***

0.341

***

0.325

***

0.573

***

0.560

***

 

CD11c (ITGAX)

0.451

***

0.373

***

0.601

***

0.540

***

0.475

***

0.462

***

 

HLA-DPA1

0.501

***

0.410

***

0.475

***

0.411

***

0.384

***

0.353

***

 

HLA-DPB1

0.426

***

0.310

***

0.466

***

0.389

***

0.458

***

0.431

***

 

HLA-DQB1

0.351

***

0.255

***

0.370

***

0.286

***

0.264

***

0.231

***

 

HLA-DRA

0.521

***

0.430

***

0.425

***

0.341

***

0.352

***

0.322

***

Th1

IFN-γ (IFNG)

0.407

***

0.324

***

0.424

***

0.345

***

0.140

*

0.128

0.021

 

STAT1

0.410

***

0.368

***

0.520

***

0.462

***

0.197

**

0.185

**

 

STAT4

0.540

***

0.457

***

0.501

***

0.420

***

0.610

***

0.594

***

 

T-bet (TBX21)

0.490

***

0.404

***

0.608

***

0.546

***

0.498

***

0.494

***

 

TNF-α (TNF)

0.285

***

0.247

***

0.407

***

0.311

***

0.182

**

0.144

*

Th2

GATA3

− 0.098

*

− 0.016

0.651

0.504

***

0.442

***

0.521

***

0.508

***

 

IL13

0.198

***

0.152

***

0.149

*

0.084

0.088

0.129

0.014

0.130

0.019

 

STAT5A

0.332

***

0.254

***

0.709

***

0.670

***

0.512

***

0.512

***

 

STAT6

0.277

***

0.274

***

0.224

***

0.255

***

0.269

***

0.283

***

Tfh

BCL6

0.215

***

0.196

***

0.301

***

0.316

***

0.601

***

0.594

***

 

IL21

0.368

***

0.314

***

0.325

***

0.288

***

0.252

***

0.239

***

Th17

IL17A

0.154

***

0.088

0.010

0.199

***

0.134

*

− 0.097

0.064

− 0.102

0.067

 

STAT3

0.343

***

0.334

***

0.297

***

0.327

***

0.495

***

0.493

***

Treg

CCR8

0.481

***

0.422

***

0.550

***

0.492

***

0.482

***

0.473

***

 

FOXP3

0.485

***

0.407

***

0.580

***

0.520

***

0.443

***

0.426

***

 

STAT5B

0.324

***

0.312

***

0.525

***

0.531

***

0.681

***

0.687

***

 

TGFβ(TGFB1)

0.298

***

0.191

***

0.485

***

0.423

***

0.546

***

0.518

***

T cell exhaustion

CTLA4

0.429

***

0.331

***

0.558

***

0.480

***

0.355

***

0.339

***

 

GZMB

0.369

***

0.265

***

0.366

***

0.270

***

0.099

0.060

0.056

0.331

 

LAG3

0.288

***

0.212

***

0.505

***

0.428

***

0.315

***

0.301

***

 

PD-1 (PDCD1)

0.394

***

0.292

***

0.529

***

0.453

***

0.419

***

0.404

***

 

TIM-3(HAVCR2)

0.421

***

0.337

***

0.526

***

0.450

***

0.418

***

0.408

***

  1. BRCA, breast invasive carcinoma; LUAD, lung adenocarcinoma; STAD stomach adenocarcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity
  2. (*P < 0.01, **P < 0.001, ***P < 0.0001)
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BMC Immunology

ISSN: 1471-2172

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