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Table 2 Correlation analysis between FNBP1 and relate genes and markers of monocyte and macrophages in GEPIA

From: Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD

Description

Gene markers

BRCA (n = 1100)

LUAD (n = 515)

STAD (n = 415)

Normal

Tumor

Normal

Tumor

Normal

Tumor

Cor

P

Cor

P

Cor

P

Cor

P

Cor

P

Cor

P

CD8+ T cell

CD8A

0.450

***

0.51

***

0.530

***

0.470

***

− 0.31

***

0.240

***

 

CD8B

0.360

***

0.34

***

0.41

***

0.300

***

− 0.32

***

0.059

0.230

T cell (general)

CD2

0.440

***

0.56

***

0.32

***

0.550

***

− 0.28

***

0.260

***

 

CD3D

0.410

***

0.44

***

0.39

***

0.410

***

− 0.22

**

0.340

***

 

CD3E

0.440

***

0.5

***

0.41

***

0.570

***

− 0.28

***

0.290

***

B cell

CD19

0.300

***

0.33

***

0.2

***

0.350

***

− 0.11

0.12

0.400

***

 

CD79A

0.350

***

0.33

***

0.035

0.51

0.230

***

− 0.14

*

0.350

***

Monocyte

CD115(CSF1R)

0.290

***

0.490

***

− 0.010

0.860

0.630

***

0.200

*

0.580

***

 

CD86

0.350

***

0.490

***

0.065

0.23

0.56

***

0.23

**

0.46

***

TAM

CCL2

0.023

0.700

0.320

***

0.22

**

0.34

***

0.51

***

0.47

***

 

CD68

0.170

*

0.450

***

− 0.3

***

0.44

***

0.059

0.39

0.2

***

 

IL10

0.000

1.000

0.450

***

− 0.160

*

0.440

***

0.380

***

0.460

***

M1 Macrophage

COX2(PTGS2)

0.280

***

0.270

***

0.340

***

0.014

0.750

0.290

**

0.130

*

 

INOS(NOS2)

0.038

0.520

0.160

***

0.380

***

0.200

***

− 0.059

0.390

− 0.011

0.820

 

IRF5

0.280

***

0.280

***

− 0.002

0.970

0.450

***

0.034

0.630

0.320

***

M2 Macrophage

CD163

− 0.130

0.026

0.350

***

− 0.370

***

0.490

***

0.510

***

0.430

***

 

MS4A4A

0.056

0.340

0.430

***

− 0.33

***

0.46

***

0.54

***

0.5

***

 

VSIG4

− 0.098

0.096

0.320

***

− 0.450

***

0.410

***

0.490

***

0.410

***

Neutrophils

CCR7

0.230

***

0.22

***

0.21

***

0.470

***

0.069

0.32

0.370

***

 

CD11b(ITGAM)

0.180

**

0.26

***

− 0.11

*

0.450

***

0.53

***

0.220

***

 

CD66b(CEACAM8)

− 0.062

0.29

− 0.018

0.55

0.14

**

− 0.021

0.65

0.068

0.33

0.011

0.83

Natural killer cell

KIR2DL1

− 0.072

0.22

0.004

0.9

0.42

***

− 0.038

0.41

− 0.003

0.97

0.041

0.41

 

KIR2DL3

0.072

0.22

0.24

***

0.43

***

0.073

0.11

0.023

0.74

0.047

0.34

 

KIR2DL4

− 0.025

0.67

0.29

***

0.18

***

0.120

**

− 0.16

*

− 0.065

0.19

 

KIR2DS4

− 0.028

0.63

0.18

***

0.39

***

0.027

0.55

0.037

0.59

0.045

0.36

 

KIR3DL1

− 0.043

0.46

0.26

***

0.35

***

0.088

0.054

0.043

0.53

0.120

*

 

KIR3DL2

0.160

**

0.25

***

0.41

***

− 0.016

0.72

− 0.15

*

0.120

*

 

KIR3DL3

0.010

0.86

0.043

0.16

0.052

0.34

0.094

*

− 0.11

0.1

− 0.062

0.21

Dendritic cell

BDCA-1(CD1C)

0.430

***

0.36

***

− 0.039

0.47

0.140

**

0.097

0.16

0.470

***

 

BDCA-4(NRP1)

0.008

0.89

0.31

***

0.54

***

0.260

***

0.65

***

0.330

***

 

CD11c (ITGAX)

0.170

**

0.41

***

0.42

***

0.430

***

0.14

*

0.230

***

 

HLA-DPA1

0.400

***

0.5

***

0.058

0.28

0.440

***

− 0.027

0.7

0.160

***

 

HLA-DPB1

0.370

***

0.42

***

0.06

0.26

0.370

***

0.038

0.59

0.230

***

 

HLA-DQB1

0.230

***

0.25

***

0.19

***

0.200

***

− 0.094

0.17

0.048

0.34

 

HLA-DRA

0.380

***

0.5

***

− 0.046

0.4

0.350

***

− 0.078

0.26

0.190

***

Th1

IFN-γ (IFNG)

0.270

***

0.34

***

0.41

***

0.380

***

− 0.048

0.48

0.035

0.48

 

STAT1

0.350

***

0.41

***

0.32

***

0.530

***

0.43

***

0.052

0.3

 

STAT4

0.240

***

0.55

***

0.71

***

0.310

***

− 0.07

0.31

0.390

***

 

T-bet (TBX21)

0.300

***

0.54

***

0.71

***

0.17

***

− 0.21

***

0.240

***

 

TNF-α (TNF)

0.290

***

0.27

***

0.24

***

0.32

***

0.23

***

− 0.010

0.84

Th2

GATA3

0.470

***

− 0.11

***

0.67

***

0.097

*

− 0.031

0.65

0.290

***

 

IL13

0.110

0.069

0.23

***

0.07

0.19

0.11

*

0.41

***

0.051

0.3

 

STAT5A

− 0.370

***

0.34

***

0.5

***

0.7

***

0.8

***

0.340

***

 

STAT6

0.360

***

0.3

***

0.39

***

0.23

***

0.58

***

0.130

*

Tfh

BCL6

− 0.099

0.091

0.16

***

0.18

***

0.32

***

0.46

***

0.580

***

 

IL21

0.290

***

0.46

***

0.074

0.17

0.39

***

− 0.09

0.19

0.150

***

Th17

IL17A

0.067

0.26

0.079

**

0.06

0.27

0.19

***

− 0.11

0.097

− 0.074

0.14

 

STAT3

0.340

***

0.36

***

0.34

***

0.36

***

0.66

***

0.330

***

Treg

CCR8

0.350

***

0.39

***

0.24

***

0.5

***

− 0.1

0.14

0.240

***

 

FOXP3

0.500

***

0.52

***

0.24

***

0.5

***

− 0.1

0.13

0.190

***

 

STAT5B

0.410

***

0.28

***

0.67

***

0.5

***

0.87

***

0.690

***

 

TGFβ(TGFB1)

0.160

**

0.14

***

0.7

***

0.37

***

0.56

***

0.350

***

T cell exhaustion

CTLA4

0.330

***

0.51

***

0.42

***

0.42

***

− 0.14

*

0.014

0.78

 

GZMB

0.130

*

0.34

***

− 0.11

*

0.25

***

− 0.088

0.2

− 0.016

0.74

 

LAG3

0.330

***

0.3

***

0.63

***

0.36

***

0.39

***

0.057

0.25

 

PD-1 (PDCD1)

0.340

***

0.44

***

0.42

***

0.42

***

− 0.11

0.11

0.190

***

 

TIM-3(HAVCR2)

0.140

*

0.44

***

0.16

**

0.49

***

0.45

***

0.170

***

  1. BRCA, breast invasive carcinoma; LUAD, lung adenocarcinoma; STAD stomach adenocarcinoma; TAM, tumor-associated macrophage; Tumor, correlation analysis in tumor tissue of TCGA. Normal, correlation analysis in normal tissue of TCGA
  2. (*P < 0.01, **P < 0.001, ***P < 0.0001)
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BMC Immunology

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