Fig. 2

Multivariate linear regression modeling validation in test set. A. Comparison of mean-squared error between testing (JHMI) and validation (DHMC) data sets for each functional assay across cross-validation replicates. Dotted line indicates median performance on permuted data in the setting of repeated cross-validation. B. Correlation between predicted and observed responses in the discovery (JHMI, blue) and validation (DHMC, green) cohorts. Pearson correlation (Rp) and mean squared error (MSE) are reported in inset. Dotted line indicates x = y