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Fig. 3 | BMC Immunology

Fig. 3

From: ThPOK inhibits the immune escape of gastric cancer cells by inducing STPG1 to inactivate the ERK pathway

Fig. 3

ThPOK induces upregulation of STPG1 in gastric cancer cells at the transcription level. A STPG1 level in gastric cancer tissues (n = 21) and adjacent normal tissues (n = 21) was assessed by RT-qPCR. B The expression of STPG1 in gastric cancer cells (HGC-27, SNU-1) and normal gastric mucosal cells (GES-1) was assessed by RT-qPCR. C RT-qPCR and western blotting were used to measure the knockdown efficiency of ThPOK in gastric cancer cells. D STPG1 mRNA and protein expression in gastric cancer cells posttransfection of sh-ThPOK#1/2. E The binding between ThPOK and the promoter region of STPG1 after the transfection of sh-ThPOK#1/2 was explored by luciferase reporter assay. F ChIP assay was used to verify the binding between ThPOK and STPG1 promoter. *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Immunology

ISSN: 1471-2172

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