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Fig. 1 | BMC Immunology

Fig. 1

From: Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers

Fig. 1

CD8+ T cells are exhausted in HBV carriers. A Flow cytometric detection of PD1, TIM3, LAG3, and CTLA4 expression on CD8+ T cells among PBMCs from HCs and HBV carriers; B differential expression of inhibitory receptors in CD8+ T cells between HCs and HBV carriers (calculated by the percentage of IR+CXCR5+CD8+ T cells plus the percentage of IR+CXCR5−CD8+ T cells); C differential mRNA expression of TOX, PD1, TIM3, and CTLA4 in PBMCs between HCs and HBV carriers. HCs: healthy controls (n = 23), HBV: hepatitis B virus carriers (n = 31); data are presented as the means ± SEs; FDR correction was used to correct the P values for comparisons between controls and patients. *P < 0.05 and **P < 0.01

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