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Fig. 4 | BMC Immunology

Fig. 4

From: Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy

Fig. 4

Combination therapy shows decrease in total and M2 macrophage recruitment. A Total TAM recruitment through IHC quantification using CD68 (40X, scale bars are 20 μm). B M2 TAM recruitment through IHC quantification using CD163. The average number of positively stained C CD68 (n = 27 FOVs per group) and D CD163 (n = 27 FOVs per group). TAMs were counted per FOV. Then the E ratio of M2 TAMs to total TAMs was calculated. A mixed effects model was used to calculate statistical differences (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). Plots created in Prism (GraphPad)

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BMC Immunology

ISSN: 1471-2172

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